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Nutrients 2015, 7(4), 2562-2573; doi:10.3390/nu7042562

Serum Phosphorus Levels in Premature Infants Receiving a Donor Human Milk Derived Fortifier

USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Section of Neonatology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX 77030, USA
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Received: 13 November 2014 / Revised: 11 March 2015 / Accepted: 30 March 2015 / Published: 9 April 2015
(This article belongs to the Special Issue Recent Advances in Enteral Nutrition)
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Abstract

An elevated serum phosphorus (P) has been anecdotally described in premature infants receiving human milk fortified with donor human milk-derived fortifier (HMDF). No studies have prospectively investigated serum P in premature infants receiving this fortification strategy. In this single center prospective observational cohort study, extremely premature infants ≤1250 grams (g) birth weight (BW) were fed an exclusive human milk-based diet receiving HMDF and serum P levels were obtained. We evaluated 93 infants with a mean gestational age of 27.5 ± 2.0 weeks (Mean ± SD) and BW of 904 ± 178 g. Seventeen infants (18.3%) had at least one high serum P level with a mean serum P of 9.2 ± 1.1 mg/dL occurring at 19 ± 11 days of life. For all infants, the highest serum P was inversely correlated to the day of life of the infant (p < 0.001, R2 = 0.175) and positively correlated with energy density of HMDF (p = 0.035). Serum P was not significantly related to gender, BW, gestational age, or days to full feeds. We conclude that the incidence of hyperphosphatemia was mild and transient in this population. The risk decreased with infant age and was unrelated to gender, BW, or ethnicity. View Full-Text
Keywords: neonate; phosphorus; hyperphosphatemia; human milk; exclusive human milk-based diet; human milk-derived fortifier; prematurity; creatinine; donor milk; very low birth weight neonate; phosphorus; hyperphosphatemia; human milk; exclusive human milk-based diet; human milk-derived fortifier; prematurity; creatinine; donor milk; very low birth weight
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Chetta, K.E.; Hair, A.B.; Hawthorne, K.M.; Abrams, S.A. Serum Phosphorus Levels in Premature Infants Receiving a Donor Human Milk Derived Fortifier. Nutrients 2015, 7, 2562-2573.

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