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Nutrients 2015, 7(3), 2015-2025; doi:10.3390/nu7032015

The Controversial Role of Food Allergy in Infantile Colic: Evidence and Clinical Management

1
Department of Translational Medical Science and European Laboratory for the Investigation of Food Induced Diseases, CEINGE—Advanced Biotechnologies University of Naples "Federico II", 80131 Naples, Italy
2
UOC of Gastroenterology "Arnas Civico", 90127 Palermo post code, Italy
*
Author to whom correspondence should be addressed.
Received: 18 December 2014 / Revised: 16 February 2015 / Accepted: 11 March 2015 / Published: 19 March 2015
(This article belongs to the Special Issue Microbiome and Human Health)
View Full-Text   |   Download PDF [431 KB, uploaded 19 March 2015]   |  

Abstract

Food allergies (FAs) are an increasing problem in Western countries, affecting up to 10% of young children. FAs are frequently associated with gastrointestinal manifestations. The role of FAs as a potential causative factor for infantile colic (IC) is still controversial. We report the most recent evidence on the pathogenesis, clinical and diagnostic aspects of FA-induced infantile colic (IC) and suggest a stepwise diagnostic approach. We selected articles on clinical and immunologic features, pathogenesis and management of FAs and IC from of 1981 to 2015. Original and review articles were identified through selective searches performed on PubMed, using the following terms: colic, infantile colic, food allergy and infantile colic, infantile colic treatment. The possible relationship between FAs and IC derives from the presence of dysmotility with visceral hypersensitivity and dysbiosis, demonstrated in both conditions, and the clinical response to dietary interventions. Unfortunately, the design of the studies, poor characterization of atopy and different dietary approaches limit the understanding of the importance of FAs in subjects with IC. The role of FAs in IC subjects without other symptoms of atopy remains controversial. However, where there is a suspicion of FAs, a short trial with an extensively hydrolyzed cow’s proteins formula or, if breast fed, with maternal elimination diet may be considered a reasonable option. View Full-Text
Keywords: cow’s milk allergy; oral food challenge; skin prick test; atopy patch test; hypoallergenic formulas; intestinal microbiota; nutrition cow’s milk allergy; oral food challenge; skin prick test; atopy patch test; hypoallergenic formulas; intestinal microbiota; nutrition
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Nocerino, R.; Pezzella, V.; Cosenza, L.; Amoroso, A.; Di Scala, C.; Amato, F.; Iacono, G.; Canani, R.B. The Controversial Role of Food Allergy in Infantile Colic: Evidence and Clinical Management. Nutrients 2015, 7, 2015-2025.

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