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Nutrients 2015, 7(3), 1378-1425; doi:10.3390/nu7031378

The Periconceptional Environment and Cardiovascular Disease: Does In Vitro Embryo Culture and Transfer Influence Cardiovascular Development and Health?

Early Origins of Adult Health Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, SA 5001, Australia
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Received: 21 November 2014 / Revised: 22 January 2015 / Accepted: 30 January 2015 / Published: 18 February 2015
(This article belongs to the Special Issue Nutrition in Pregnancy)
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Abstract

Assisted Reproductive Technologies (ARTs) have revolutionised reproductive medicine; however, reports assessing the effects of ARTs have raised concerns about the immediate and long-term health outcomes of the children conceived through ARTs. ARTs include manipulations during the periconceptional period, which coincides with an environmentally sensitive period of gamete/embryo development and as such may alter cardiovascular development and health of the offspring in postnatal life. In order to identify the association between ARTs and cardiovascular health outcomes, it is important to understand the events that occur during the periconceptional period and how they are affected by procedures involved in ARTs. This review will highlight the emerging evidence implicating adverse cardiovascular outcomes before and after birth in offspring conceived through ARTs in both human and animal studies. In addition, it will identify the potential underlying causes and molecular mechanisms responsible for the congenital and adult cardiovascular dysfunctions in offspring whom were conceived through ARTs. View Full-Text
Keywords: assisted reproductive technology; in vitro fertilization; periconceptional period; cardiovascular disease; epigenetics assisted reproductive technology; in vitro fertilization; periconceptional period; cardiovascular disease; epigenetics
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Padhee, M.; Zhang, S.; Lie, S.; Wang, K.C.; Botting, K.J.; McMillen, I.C.; MacLaughlin, S.M.; Morrison, J.L. The Periconceptional Environment and Cardiovascular Disease: Does In Vitro Embryo Culture and Transfer Influence Cardiovascular Development and Health? Nutrients 2015, 7, 1378-1425.

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