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Nutrients 2015, 7(2), 815-830; doi:10.3390/nu7020815

Chronic Prosopis Glandulosa Treatment Blunts Neutrophil Infiltration and Enhances Muscle Repair after Contusion Injury

1
Department of Biomedical Sciences, Faculty of Health Science, Stellenbosch University, Tygerberg 7505, South Africa
2
Department of Physiological Sciences, Faculty of Science, Stellenbosch University, Stellenbosch 7600, South Africa
3
Medical Research Council, Diabetes Discovery Platform, Francie van Zijl Drive, Parowvallei, Tygerberg 7505, South Africa
*
Author to whom correspondence should be addressed.
Received: 19 September 2014 / Accepted: 9 January 2015 / Published: 23 January 2015
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Abstract

The current treatment options for soft tissue injuries remain suboptimal and often result in delayed/incomplete recovery of damaged muscle. The current study aimed to evaluate the effects of oral Prosopis glandulosa treatment on inflammation and regeneration in skeletal muscle after contusion injury, in comparison to a conventional treatment. The gastrocnemius muscle of rats was subjected to mass-drop injury and muscle samples collected after 1-, 3 h, 1- and 7 days post-injury. Rats were treated with P. glandulosa (100 mg/kg/day) either for 8 weeks prior to injury (up until day 7 post-injury), only post-injury, or with topically applied diclofenac post-injury (0.57 mg/kg). Neutrophil (His48-positive) and macrophage (F4/80-positive) infiltration was assessed by means of immunohistochemistry. Indicators of muscle satellite cell proliferation (ADAM12) and regeneration (desmin) were used to evaluate muscle repair. Chronic P. glandulosa and diclofenac treatment (p < 0.0001) was associated with suppression of the neutrophil response to contusion injury, however only chronic P. glandulosa treatment facilitated more effective muscle recovery (increased ADAM12 (p < 0.05) and desmin (p < 0.001) expression), while diclofenac treatment had inhibitory effects on repair, despite effective inhibition of neutrophil response. Data indicates that P. glandulosa treatment results in more effective muscle repair after contusion. View Full-Text
Keywords: fabaceae; inflammation; mass-drop injury; NSAID; regeneration fabaceae; inflammation; mass-drop injury; NSAID; regeneration
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

George, C.; Smith, C.; Isaacs, A.W.; Huisamen, B. Chronic Prosopis Glandulosa Treatment Blunts Neutrophil Infiltration and Enhances Muscle Repair after Contusion Injury. Nutrients 2015, 7, 815-830.

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