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Nutrients 2015, 7(12), 9860-9871; doi:10.3390/nu7125504

Study of Anti-Fatigue Effect in Rats of Ferrous Chelates Including Hairtail Protein Hydrolysates

1
School of Marine Science and Technology, Zhejiang Ocean University, No.1, Haida South Road, Lincheng Changzhi island, Zhoushan 316022, China
2
School of Food and Medicine, Zhejiang Ocean University, No.1, Haida South Road, Lincheng ChangzhiIsland, Zhoushan 316022, China
*
Author to whom correspondence should be addressed.
Received: 24 October 2015 / Revised: 16 November 2015 / Accepted: 18 November 2015 / Published: 1 December 2015
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Abstract

The ability of ferrous chelates including hairtail protein hydrolysates to prevent and reduce fatigue was studied in rats. After hydrolysis of hairtail surimi with papain, the hairtail protein hydrolysates (HPH) were separated into three groups by range of relative molecular weight using ultrafiltration membrane separation. Hairtail proteins were then chelated with ferrous ions, and the antioxidant activity, the amino acid composition and chelation rate of the three kinds of ferrous chelates including hairtail protein hydrolysates (Fe-HPH) were determined. Among the three groups, the Fe-HPH chelate showing the best conditions was selected for the anti-fatigue animal experiment. For it, experimental rats were randomly divided into seven groups. Group A was designated as the negative control group given distilled water. Group B, the positive control group, was given glutathione. Groups C, D and E were designated as the Fe-HPH chelate treatment groups and given low, medium, and high doses, respectively. Group F was designated as HPH hydrolysate treatment group, and Group G was designated as FeCl2 treatment group. The different diets were orally administered to rats for 20 days. After that time, rats were subjected to forced swimming training after 1 h of gavage. Rats given Fe-FPH chelate had higher haemoglobin regeneration efficiency (HRE), longer exhaustive swimming time and higher SOD activity. Additionally, Fe-FPH chelate was found to significantly decrease the malondialdehyde content, visibly enhance the GSH-Px activity in liver and reduce blood lactic acid of rats. Fe-HPH chelate revealed an anti-fatigue effect, similar to or better than the positive control substance and superior to HPH or Fe when provided alone. View Full-Text
Keywords: hairtail protein peptide; ferrous ion; chelate; anti-fatigue; rat hairtail protein peptide; ferrous ion; chelate; anti-fatigue; rat
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Huang, S.; Lin, H.; Deng, S.-G. Study of Anti-Fatigue Effect in Rats of Ferrous Chelates Including Hairtail Protein Hydrolysates. Nutrients 2015, 7, 9860-9871.

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