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Nutrients 2015, 7(12), 10237-10250; doi:10.3390/nu7125531

Fermented Brown Rice and Rice Bran with Aspergillus oryzae (FBRA) Prevents Inflammation-Related Carcinogenesis in Mice, through Inhibition of Inflammatory Cell Infiltration

1
Division of Pathological Biochemistry, Tottori University Faculty of Medicine, Tottori 683-8503, Japan
2
Japanese Red Cross Society, Minato-ku, Tokyo 105-8521, Japan
3
School of Nursing and Social Services, Health Sciences University of Hokkaido, 1757 Kanazawa, Ishikari-Tobetsu, Hokkaido 061-0293, Japan
4
Chromosome Engineering Research Center, Tottori University, Tottori 683-8503, Japan
5
Genmai Koso Co., Ltd., Sapporo, Hokkaido 001-0012, Japan
6
Sapporo Cancer Seminar Foundation, Sapporo, Hokkaido 001-0012, Japan
*
Author to whom correspondence should be addressed.
Received: 27 October 2015 / Revised: 13 November 2015 / Accepted: 26 November 2015 / Published: 8 December 2015
(This article belongs to the Special Issue Cereal Grains for Human Health)
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Abstract

We have established an inflammation-related carcinogenesis model in mouse, in which regressive QR-32 cells subcutaneously co-implanted with a foreign body—gelatin sponge—convert themselves into lethal tumors due to massive infiltration of inflammatory cells into the sponge. Animals were fed with a diet containing 5% or 10% fermented brown rice and rice bran with Aspergillus oryzae (FBRA). In 5% and 10% FBRA diet groups, tumor incidences were lower (35% and 20%, respectively) than in the non-treated group (70%). We found that FBRA reduced the number of inflammatory cells infiltrating into the sponge. FBRA administration did not cause myelosuppression, which indicated that the anti-inflammatory effects of FBRA took place at the inflammatory lesion. FBRA did not have antitumor effects on the implanted QRsP-11 tumor cells, which is a tumorigenic cell line established from a tumor arisen after co-implantation of QR-32 cells with sponge. FBRA did not reduce formation of 8-hydroxy-2′-deoxyguanine adducts, a marker of oxidative DNA damage in the inflammatory lesion; however, it reduced expression of inflammation-related genes such as TNF-α, Mac-1, CCL3 and CXCL2. These results suggest that FBRA will be an effective chemopreventive agent against inflammation-related carcinogenesis that acts by inhibiting inflammatory cell infiltration into inflammatory lesions. View Full-Text
Keywords: fermented brown rice and rice bran with Aspergillus oryzae (FBRA); inflammation-related carcinogenesis; inflammation fermented brown rice and rice bran with Aspergillus oryzae (FBRA); inflammation-related carcinogenesis; inflammation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Onuma, K.; Kanda, Y.; Suzuki Ikeda, S.; Sakaki, R.; Nonomura, T.; Kobayashi, M.; Osaki, M.; Shikanai, M.; Kobayashi, H.; Okada, F. Fermented Brown Rice and Rice Bran with Aspergillus oryzae (FBRA) Prevents Inflammation-Related Carcinogenesis in Mice, through Inhibition of Inflammatory Cell Infiltration. Nutrients 2015, 7, 10237-10250.

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