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Nutrients 2015, 7(12), 10129-10144; doi:10.3390/nu7125524

Advanced Glycation End Products: Link between Diet and Ovulatory Dysfunction in PCOS?

1
Department of Obstetrics and Gynecology, Maimonides Medical Center, Brooklyn, NY 11219, USA
2
Department of Obstetrics and Gynecology, Division of Reproductive Biology, School of Medicine, New York University, 180 Varick St., Sixth Floor, New York, NY 11014, USA
*
Author to whom correspondence should be addressed.
Received: 21 August 2015 / Revised: 22 October 2015 / Accepted: 24 November 2015 / Published: 4 December 2015
(This article belongs to the Special Issue Premenopausal Nutrition and Fertility)
View Full-Text   |   Download PDF [579 KB, uploaded 4 December 2015]   |  

Abstract

PCOS is the most common cause of anovulation in reproductive-aged women with 70% experiencing ovulatory problems. Advanced glycation end products are highly reactive molecules that are formed by non-enzymatic reactions of sugars with proteins, nucleic acids and lipids. AGEs are also present in a variety of diet where substantial increase in AGEs can result due to thermal processing and modifications of food. Elevation in bodily AGEs, produced endogenously or absorbed exogenously from high-AGE diets, is further exaggerated in women with PCOS and is associated with ovulatory dysfunction. Additionally, increased expression of AGEs as pro-inflammatory receptors in the ovarian tissue has been observed in women with PCOS. In this review, we summarize the role of dietary AGEs as mediators of metabolic and reproductive alterations in PCOS. Once a mechanistic understanding of the relationship between AGEs and anovulation is established, there is a promise that such knowledge will contribute to the subsequent development of targeted pharmacological therapies that will treat anovulation and improve ovarian health in women with PCOS. View Full-Text
Keywords: advanced glycation end products; receptor for advanced glycation endproducts (RAGE); soluble receptor for advanced glycation end products (sRAGE); polycystic ovary syndrome (PCOS); anovulation advanced glycation end products; receptor for advanced glycation endproducts (RAGE); soluble receptor for advanced glycation end products (sRAGE); polycystic ovary syndrome (PCOS); anovulation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Garg, D.; Merhi, Z. Advanced Glycation End Products: Link between Diet and Ovulatory Dysfunction in PCOS? Nutrients 2015, 7, 10129-10144.

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