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Nutrients 2015, 7(11), 9163-9170; doi:10.3390/nu7115458

Iron Metabolism Dysregulation and Cognitive Dysfunction in Pediatric Obesity: Is There a Connection?

Department of Woman, Child, General and Specialized Surgery, Second University of Naples Via De Crecchio 2–4, Naples 80138, Italy
Author to whom correspondence should be addressed.
Received: 10 August 2015 / Revised: 23 October 2015 / Accepted: 29 October 2015 / Published: 6 November 2015
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Obesity and iron deficiency (ID) are two of the most common nutritional disorders in the world. In children both conditions deserve particular attention. Several studies revealed an association between obesity and iron deficiency in children and, in some cases, a reduced response to oral supplementation. The connecting mechanism, however, is not completely known. This review is focused on: (1) iron deficiency in obese children and the role of hepcidin in the connection between body fat and poor iron status; (2) iron status and consequences on health, in particular on cognitive function; (3) cognitive function and obesity; (4) suggestion of a possible link between cognitive dysfunction and ID in pediatric obesity; and implications for therapy and future research. View Full-Text
Keywords: obesity; iron deficiency; cognitive dysfunction; hepcidin; children obesity; iron deficiency; cognitive dysfunction; hepcidin; children

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Grandone, A.; Marzuillo, P.; Perrone, L.; del Giudice, E.M. Iron Metabolism Dysregulation and Cognitive Dysfunction in Pediatric Obesity: Is There a Connection? Nutrients 2015, 7, 9163-9170.

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