Next Article in Journal
Iron Metabolism Dysregulation and Cognitive Dysfunction in Pediatric Obesity: Is There a Connection?
Next Article in Special Issue
Dietary Patterns during Pregnancy Are Associated with Risk of Gestational Diabetes Mellitus
Previous Article in Journal / Special Issue
Definition of the Mediterranean Diet; A Literature Review
Article Menu

Export Article

Open AccessArticle
Nutrients 2015, 7(11), 9154-9162; doi:10.3390/nu7115457

Better Adherence to the Mediterranean Diet Could Mitigate the Adverse Consequences of Obesity on Cardiovascular Disease: The SUN Prospective Cohort

1
Servicio Navarro de Salud-Osasunbidea-IdiSNA, Navarra Institute for Health Research, 31002 Pamplona, Spain
2
Department of Preventive Medicine and Public Health, Navarra Institute for Health Research, University of Navarra-IdiSNA, 31008 Pamplona, Spain
3
Biomedical Research Center Network on Obesity and Nutrition (CIBERobn) Physiopathology of Obesity and Nutrition, Instituto de Salud Carlos III, 28029 Madrid, Spain
4
Department of Cardiology, Navarra Institute for Health Research, University Clinic of Navarra-IdiSNA, 31008 Pamplona, Spain
5
Department of Radiology, Hospital of Navarra, Servicio Navarro de Salud-Osasunbidea-IdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain
*
Author to whom correspondence should be addressed.
Received: 22 August 2015 / Revised: 25 October 2015 / Accepted: 29 October 2015 / Published: 5 November 2015
(This article belongs to the Special Issue Dietary Pattern and Health)
View Full-Text   |   Download PDF [845 KB, uploaded 9 November 2015]   |  

Abstract

Strong observational evidence supports the association between obesity and cardiovascular events. In elderly high-risk subjects, the Mediterranean diet (MedDiet) was reported to counteract the adverse cardiovascular effects of adiposity. Whether this same attenuation is also present in younger subjects is not known. We prospectively examined the association between obesity and cardiovascular clinical events (myocardial infarction, stroke or cardiovascular death) after 10.9 years follow-up in 19,065 middle-aged men and women (average age 38 year) according to their adherence to the MedDiet (<6 points or ≥6 points in the Trichopoulou’s Mediterranean Diet Score). We observed 152 incident cases of cardiovascular disease (CVD). An increased risk of CVD across categories of body mass index (BMI) was apparent if adherence to the MedDiet was low, with multivariable-adjusted hazard ratios (HRs): 1.44 (95% confidence interval: 0.93–2.25) for ≥25 – <30 kg/m2 of BMI and 2.00 (1.04–3.83) for ≥30 kg/m2 of BMI, compared to a BMI < 25 kg/m2. In contrast, these estimates were 0.77 (0.35–1.67) and 1.15 (0.39–3.43) with good adherence to MedDiet. Better adherence to the MedDiet was associated with reduced CVD events (p for trend = 0.029). Our results suggest that the MedDiet could mitigate the harmful cardiovascular effect of overweight/obesity. View Full-Text
Keywords: obesity; Mediterranean diet; prospective cohort study; cardiovascular disease; SUN project obesity; Mediterranean diet; prospective cohort study; cardiovascular disease; SUN project
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Eguaras, S.; Toledo, E.; Hernández-Hernández, A.; Cervantes, S.; Martínez-González, M.A. Better Adherence to the Mediterranean Diet Could Mitigate the Adverse Consequences of Obesity on Cardiovascular Disease: The SUN Prospective Cohort. Nutrients 2015, 7, 9154-9162.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top