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Nutrients 2015, 7(10), 8444-8455; doi:10.3390/nu7105405

Association of Body Mass Index and Body Mass Index Change with Mortality in Incident Peritoneal Dialysis Patients

1
Department of Nephrology, The First Affiliated Hospital of Sun Yat-sen University, Key Laboratory of Nephrology, Ministry of Health of China, Guangdong Provincial Key Laboratory of Nephrology, Guangzhou 510080, China
2
Epidemiology Research Unit and Translational Medicine Research Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 17 July 2015 / Revised: 17 September 2015 / Accepted: 28 September 2015 / Published: 13 October 2015
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Abstract

Although high body mass index (BMI) appears to confer a survival advantage in hemodialysis patients, the association of BMI with mortality in continuous ambulatory peritoneal dialysis (CAPD) patients is uncertain. We enrolled incident CAPD patients and BMI was categorized according to World Health Organization classification for Asian population. BMI at baseline and one year after the initiation of peritoneal dialysis (PD) treatment was assessed to calculate the BMI change (∆BMI). Patients were split into four categories according quartiles of ∆BMI. Kaplan-Meier method and Cox regression proportional hazard analysis were performed to assess the association of BMI on outcomes. A total of 1263 CAPD patients were included, with a mean age of 47.8 ± 15.0 years, a mean BMI of 21.58 ± 3.13 kg/m2. During a median follow-up of 25.3 months, obesity was associated with increased risk for cardiovascular diseases (CVD) death (adjusted hazard ratio (AHR) 2.01; 95% CI 1.14, 3.54), but not all-cause mortality. Additionally, patients with more BMI decline (>0.80%) during the first year after CAPD initiation had an elevated risk for both all-cause (AHR: 2.21, 95% CI 1.23–3.95) and CVD mortality (AHR 2.31, 95% CI 1.11, 4.84), which was independent of baseline BMI values. View Full-Text
Keywords: continuous ambulatory peritoneal dialysis; body mass index; body mass index change; mortality continuous ambulatory peritoneal dialysis; body mass index; body mass index change; mortality
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Xiong, L.; Cao, S.; Xu, F.; Zhou, Q.; Fan, L.; Xu, Q.; Yu, X.; Mao, H. Association of Body Mass Index and Body Mass Index Change with Mortality in Incident Peritoneal Dialysis Patients. Nutrients 2015, 7, 8444-8455.

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