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Nutrients 2014, 6(8), 3101-3116; doi:10.3390/nu6083101

Glutamine Attenuates Acute Lung Injury Caused by Acid Aspiration

1
Department of Intensive Care Medicine, Chi Mei Medical Center, Liouying Dist., Tainan 73657 Taiwan
2
Department of Recreation and Health-Care Management, Chia Nan University of Pharmacy and Science, Tainan 71710, Taiwan
3
Chang Jung Christian University, Tainan 71101, Taiwan
4
Departments of Intensive Care Medicine, Chi Mei Medical Center, Tainan, 71073, Taiwan
*
Author to whom correspondence should be addressed.
Received: 18 June 2014 / Revised: 14 July 2014 / Accepted: 24 July 2014 / Published: 5 August 2014
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Abstract

Inadequate ventilator settings may cause overwhelming inflammatory responses associated with ventilator-induced lung injury (VILI) in patients with acute respiratory distress syndrome (ARDS). Here, we examined potential benefits of glutamine (GLN) on a two-hit model for VILI after acid aspiration-induced lung injury in rats. Rats were intratracheally challenged with hydrochloric acid as a first hit to induce lung inflammation, then randomly received intravenous GLN or lactated Ringer’s solution (vehicle control) thirty min before different ventilator strategies. Rats were then randomized to receive mechanical ventilation as a second hit with a high tidal volume (TV) of 15 mL/kg and zero positive end-expiratory pressure (PEEP) or a low TV of 6 mL/kg with PEEP of 5 cm H2O. We evaluated lung oxygenation, inflammation, mechanics, and histology. After ventilator use for 4 h, high TV resulted in greater lung injury physiologic and biologic indices. Compared with vehicle treated rats, GLN administration attenuated lung injury, with improved oxygenation and static compliance, and decreased respiratory elastance, lung edema, extended lung destruction (lung injury scores and lung histology), neutrophil recruitment in the lung, and cytokine production. Thus, GLN administration improved the physiologic and biologic profiles of this experimental model of VILI based on the two-hit theory. View Full-Text
Keywords: acid aspiration; ARDS; glutamine; ventilator-induced lung injury acid aspiration; ARDS; glutamine; ventilator-induced lung injury
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Lai, C.-C.; Liu, W.-L.; Chen, C.-M. Glutamine Attenuates Acute Lung Injury Caused by Acid Aspiration. Nutrients 2014, 6, 3101-3116.

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