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Nutrients 2014, 6(6), 2179-2195; doi:10.3390/nu6062179

Sasa borealis Stem Extract Attenuates Hepatic Steatosis in High-Fat Diet-induced Obese Rats

1
Institute of Agriculture and Life Science, College of Veterinary Medicine, Gyeongsang National University, Jinju 660-701, Korea
2
Department of Foods and Nutrition, Gyeongsang National University, Jinju 660-701, Korea
3
Department of Animal Science & Biotechnology, Gyeongnam National University of Science and Technology, Jinju 660-758, Korea
4
Animal Genetic Resources Station, National Institute of Animal Science, RDA, Namwon 590-832, Korea
5
Department of Environmental Health Science, New York Medical College, Valhalla, NY 10595, USA
6
Department of Bioindustry, Daegu University, Gyungsan 712-714, Korea
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 15 April 2014 / Revised: 12 May 2014 / Accepted: 26 May 2014 / Published: 5 June 2014
(This article belongs to the Special Issue Nutrition and Liver Disease)
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Abstract

The aim of the current study is to examine the improving effect of Sasa borealis stem (SBS) extract extracts on high-fat diet (HFD)-induced hepatic steatosis in rats. To determine the hepatoprotective effect of SBS, we fed rats a normal regular diet (ND), HFD, and HFD supplemented with 150 mg/kg body weight (BW) SBS extracts for five weeks. We found that the body weight and liver weight of rats in the HFD + SBS group were significantly lower than those in the HFD group. Significantly lower serum total cholesterol (TC) and triglyceride (TG) concentrations were observed in the SBS-supplemented group compared with the HFD group. We also found that the HFD supplemented with SBS group showed dramatically reduced hepatic lipid accumulation compared to the HFD alone group, and administration of SBS resulted in dramatic suppression of TG, TC in the HFD-induced fatty liver. In liver gene expression within the SBS treated group, PPARα was significantly increased and SREBP-1c was significantly suppressed. SBS induced a significant decrease in the hepatic mRNA levels of PPARγ, FAS, ACC1, and DGAT2. In conclusion, SBS improved cholesterol metabolism, decreased lipogenesis, and increased lipid oxidation in HFD-induced hepatic steatosis in rats, implying a potential application in treatment of non-alcoholic fatty liver disease. View Full-Text
Keywords: high-fat diet; Sasa borealis stem; hepatic steatosis; hepatic gene expression high-fat diet; Sasa borealis stem; hepatic steatosis; hepatic gene expression
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Song, Y.; Lee, S.-J.; Jang, S.-H.; Ha, J.H.; Song, Y.M.; Ko, Y.-G.; Kim, H.-D.; Min, W.; Kang, S.N.; Cho, J.-H. Sasa borealis Stem Extract Attenuates Hepatic Steatosis in High-Fat Diet-induced Obese Rats. Nutrients 2014, 6, 2179-2195.

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