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Nutrients 2014, 6(4), 1737-1751; doi:10.3390/nu6041737

In Vitro Anti-Osteoporosis Properties of Diverse Korean Drynariae rhizoma Phenolic Extracts

Department of Animal Resources, Daegu University, Gyeongsan 712-714, Korea
Department of Food Science and Biotechnology, Kangwon National University, Chuncheon 200-701, Korea
Department of Food Science and Technology, Institute of Food Science, Pukyong National University, Busan 608-737, Korea
Institute of Life Science, College of Veterinary Medicine, Gyeongsang National University, Jinju 660-701, Korea
Department of Animal Resource and Science, Dankook University, Choongnam 330-714, Korea
Department of Animal Resource Technology, Gyeongnam National University of Science and Technology, Jinju 660-758, Korea
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Received: 20 February 2014 / Revised: 9 April 2014 / Accepted: 21 April 2014 / Published: 24 April 2014
View Full-Text   |   Download PDF [945 KB, uploaded 24 April 2014]   |  


Drynariae rhizoma has been used to prevent bone loss that occurs with increasing age. However, the chemical compounds in extracts that act on bone metabolism in herbal medicine are poorly understood. This study aimed to investigate and compare the extraction efficacy of polyphenolic compounds, antioxidant activity, and in vitro anti-osteoporosis properties of water extract (DR-DW) and ethanol extract (DR-EtOH) from D. rhizoma. Total phenolics and flavonoids were better extracted with 70% EtOH, and this extraction method also resulted in higher antioxidant activity and in vitro anti-osteoporosis properties in these extracts. In particular, the contents of phloroglucinol, protocatechuic acid ethyl ester, 2-amino-3,4-dimethyl-benzoic acid, 3-(3,5-dimethyl-pyrazol-1-yl)-benzoic acid, chlorogenic acid, syringic acid, trans-ferulic acid, (−)-epigallocatechin, epigallocatechin gallate, quercetin dehydrate, luteolin and emodin in DR-EtOH were higher than those in DR-DW. These results indicated that DR-EtOH could be a good source of natural herbs with anti-osteoporosis properties. View Full-Text
Keywords: Drynariae rhizoma; extraction solvent; phenolic compounds; antioxidant; anti-osteoporosis Drynariae rhizoma; extraction solvent; phenolic compounds; antioxidant; anti-osteoporosis

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MDPI and ACS Style

Kang, S.-N.; Lee, J.S.; Park, J.-H.; Cho, J.-H.; Park, J.-H.; Cho, K.-K.; Lee, O.-H.; Kim, I.-S. In Vitro Anti-Osteoporosis Properties of Diverse Korean Drynariae rhizoma Phenolic Extracts. Nutrients 2014, 6, 1737-1751.

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