Nutrients 2014, 6(3), 1262-1272; doi:10.3390/nu6031262
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Metabolic Interactions between Vitamin A and Conjugated Linoleic Acid

1email, 1email, 2email, 3email, 4email, 5email, 6email and 1,* email
Received: 23 December 2013; in revised form: 4 March 2014 / Accepted: 10 March 2014 / Published: 24 March 2014
(This article belongs to the Special Issue Vitamin A and Carotenoids)
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Abstract: Lipid-soluble molecules share several aspects of their physiology due to their common adaptations to a hydrophilic environment, and may interact to regulate their action in a tissue-specific manner. Dietary conjugated linoleic acid (CLA) is a fatty acid with a conjugated diene structure that is found in low concentrations in ruminant products and available as a nutritional supplement. CLA has been shown to increase tissue levels of retinol (vitamin A alcohol) and its sole specific circulating carrier protein retinol-binding protein (RBP or RBP4). However, the precise mechanism of this action has not been elucidated yet. Here, we provide a summary of the current knowledge in this specific area of research and speculate that retinol and CLA may compete for catabolic pathways modulated by the activity of PPAR-α and RXR heterodimer. We also present preliminary data that may position PPAR-α at the crossroads between the metabolism of lipids and vitamin A.
Keywords: conjugated linoleic acid (CLA); retinol; vitamin A; retinol binding protein (RBP); oleoylethanolamide (OEA); palmitoylethanolamide (PEA); peroxisome proliferator-activated receptor-alpha (PPARα)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Carta, G.; Murru, E.; Cordeddu, L.; Ortiz, B.; Giordano, E.; Belury, M.A.; Quadro, L.; Banni, S. Metabolic Interactions between Vitamin A and Conjugated Linoleic Acid. Nutrients 2014, 6, 1262-1272.

AMA Style

Carta G, Murru E, Cordeddu L, Ortiz B, Giordano E, Belury MA, Quadro L, Banni S. Metabolic Interactions between Vitamin A and Conjugated Linoleic Acid. Nutrients. 2014; 6(3):1262-1272.

Chicago/Turabian Style

Carta, Gianfranca; Murru, Elisabetta; Cordeddu, Lina; Ortiz, Berenice; Giordano, Elena; Belury, Martha A.; Quadro, Loredana; Banni, Sebastiano. 2014. "Metabolic Interactions between Vitamin A and Conjugated Linoleic Acid." Nutrients 6, no. 3: 1262-1272.


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