Abstract: Lipid-soluble molecules share several aspects of their physiology due to their common adaptations to a hydrophilic environment, and may interact to regulate their action in a tissue-specific manner. Dietary conjugated linoleic acid (CLA) is a fatty acid with a conjugated diene structure that is found in low concentrations in ruminant products and available as a nutritional supplement. CLA has been shown to increase tissue levels of retinol (vitamin A alcohol) and its sole specific circulating carrier protein retinol-binding protein (RBP or RBP4). However, the precise mechanism of this action has not been elucidated yet. Here, we provide a summary of the current knowledge in this specific area of research and speculate that retinol and CLA may compete for catabolic pathways modulated by the activity of PPAR-α and RXR heterodimer. We also present preliminary data that may position PPAR-α at the crossroads between the metabolism of lipids and vitamin A.
Keywords: conjugated linoleic acid (CLA); retinol; vitamin A; retinol binding protein (RBP); oleoylethanolamide (OEA); palmitoylethanolamide (PEA); peroxisome proliferator-activated receptor-alpha (PPARα)
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Carta, G.; Murru, E.; Cordeddu, L.; Ortiz, B.; Giordano, E.; Belury, M.A.; Quadro, L.; Banni, S. Metabolic Interactions between Vitamin A and Conjugated Linoleic Acid. Nutrients 2014, 6, 1262-1272.
Carta G, Murru E, Cordeddu L, Ortiz B, Giordano E, Belury MA, Quadro L, Banni S. Metabolic Interactions between Vitamin A and Conjugated Linoleic Acid. Nutrients. 2014; 6(3):1262-1272.
Carta, Gianfranca; Murru, Elisabetta; Cordeddu, Lina; Ortiz, Berenice; Giordano, Elena; Belury, Martha A.; Quadro, Loredana; Banni, Sebastiano. 2014. "Metabolic Interactions between Vitamin A and Conjugated Linoleic Acid." Nutrients 6, no. 3: 1262-1272.