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Nutrients 2014, 6(12), 5724-5739; doi:10.3390/nu6125724

Insights from Space: Potential Role of Diet in the Spatial Organization of Chromosomes

1
The Liggins Institute, The University of Auckland, Private Bag 92019 AMC, Auckland 1142, New Zealand
2
Department of Pathology, Dunedin School of Medicine, The University of Otago, P.O. Box 913, Dunedin 9054, New Zealand
*
Author to whom correspondence should be addressed.
Received: 17 September 2014 / Revised: 20 November 2014 / Accepted: 21 November 2014 / Published: 10 December 2014
(This article belongs to the Special Issue Nutritional Epigenetics)
View Full-Text   |   Download PDF [179 KB, uploaded 10 December 2014]   |  

Abstract

We can now sequence and identify genome wide epigenetic patterns and perform a variety of “genomic experiments” within relatively short periods of time—ranging from days to weeks. Yet, despite these technological advances, we have a poor understanding of the inter-relationships between epigenetics, genome structure-function, and nutrition. Perhaps this limitation lies, in part, in our propensity to study epigenetics in terms of the linear arrangement of elements and genes. Here we propose that a more complete understanding of how nutrition impacts on epigenetics and cellular development resides within the inter-relationships between DNA and histone modification patterns and genome function, in the context of spatial organization of chromatin and the epigenome. View Full-Text
Keywords: HiC; proximity ligation; genome organization; nutrition; epigenetics; estrogen; cohesion; CTCF HiC; proximity ligation; genome organization; nutrition; epigenetics; estrogen; cohesion; CTCF
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

O'Sullivan, J.M.; Doynova, M.D.; Antony, J.; Pichlmuller, F.; Horsfield, J.A. Insights from Space: Potential Role of Diet in the Spatial Organization of Chromosomes. Nutrients 2014, 6, 5724-5739.

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