Insights from Space: Potential Role of Diet in the Spatial Organization of Chromosomes
AbstractWe can now sequence and identify genome wide epigenetic patterns and perform a variety of “genomic experiments” within relatively short periods of time—ranging from days to weeks. Yet, despite these technological advances, we have a poor understanding of the inter-relationships between epigenetics, genome structure-function, and nutrition. Perhaps this limitation lies, in part, in our propensity to study epigenetics in terms of the linear arrangement of elements and genes. Here we propose that a more complete understanding of how nutrition impacts on epigenetics and cellular development resides within the inter-relationships between DNA and histone modification patterns and genome function, in the context of spatial organization of chromatin and the epigenome. View Full-Text
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O'Sullivan, J.M.; Doynova, M.D.; Antony, J.; Pichlmuller, F.; Horsfield, J.A. Insights from Space: Potential Role of Diet in the Spatial Organization of Chromosomes. Nutrients 2014, 6, 5724-5739.
O'Sullivan JM, Doynova MD, Antony J, Pichlmuller F, Horsfield JA. Insights from Space: Potential Role of Diet in the Spatial Organization of Chromosomes. Nutrients. 2014; 6(12):5724-5739.Chicago/Turabian Style
O'Sullivan, Justin M.; Doynova, Malina D.; Antony, Jisha; Pichlmuller, Florian; Horsfield, Julia A. 2014. "Insights from Space: Potential Role of Diet in the Spatial Organization of Chromosomes." Nutrients 6, no. 12: 5724-5739.