Next Article in Journal
Insights from Space: Potential Role of Diet in the Spatial Organization of Chromosomes
Previous Article in Journal
The Role of Dietary Sugars and De novo Lipogenesis in Non-Alcoholic Fatty Liver Disease
Article Menu

Export Article

Open AccessArticle
Nutrients 2014, 6(12), 5704-5723; doi:10.3390/nu6125704

Isoflavone and Protein Constituents of Lactic Acid-Fermented Soy Milk Combine to Prevent Dyslipidemia in Rats Fed a High Cholesterol Diet

1
Department of Nutritional Management, School of Health Sciences, Hyogo University, 2301 Hiraoka-cho shinzaike, Kakogawa, Hyogo 675-0195, Japan
2
Research and Development Division, MARUSAN-AI Co., Ltd., 1 Aza-Arashita, Nikki-cho, Okazaki, Aichi 444-2193, Japan
3
Department of Food Science and Nutrition, School of Human Environmental Sciences, Mukogawa Women's University, 6-46 Ikebiraki-cho, Nishinomiya, Hyogo 663-8558, Japan
*
Author to whom correspondence should be addressed.
Received: 10 July 2014 / Revised: 11 September 2014 / Accepted: 24 November 2014 / Published: 10 December 2014
View Full-Text   |   Download PDF [259 KB, uploaded 10 December 2014]   |  

Abstract

A high cholesterol diet induces dyslipidemia. This study investigated whether isoflavone aglycones in lactic acid-fermented soy milk (LFS) improve lipid metabolism in rats fed a high cholesterol diet. Male Sprague-Dawley rats aged seven weeks were fed an AIN-93G diet, a 1% cholesterol diet (a high cholesterol diet), a high-cholesterol diet containing 4% isoflavone extract of LFS (LFS extract diet), a high-cholesterol diet containing 19.4% ethanol-washed LFS (ethanol-washed LFS diet, isoflavone-poor diet), or a high cholesterol diet containing 23.2% intact LFS (intact LFS diet) for five weeks. The plasma total cholesterol (TC) level was increased in the rats fed the LFS extract diet compared with those fed the high cholesterol diet. The TC level was decreased by the intact LFS and ethanol-washed LFS diets. The cholesterol-lowering effect was stronger in the rats fed the intact LFS diet than those fed the ethanol-washed LFS diet. The plasma triglyceride (TG) level was unchanged in the rats fed the LFS extract diet, but it decreased in rats fed the intact LFS and ethanol-washed LFS diets. Although, compared with the high cholesterol diet, the LFS extract and ethanol-washed LFS diets did not reduce hepatic cholesterol and TG, both levels were remarkably lowered by the intact LFS diet. These results suggest that the improvement in lipid metabolism of rats fed a high-cholesterol diet containing LFS isoflavone aglycones is not due to an independent effect but due to a cooperative effect with soy protein. View Full-Text
Keywords: isoflavone; soy protein; fermented soy milk; cholesterol; lipid metabolism isoflavone; soy protein; fermented soy milk; cholesterol; lipid metabolism
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Kobayashi, M.; Egusa, S.; Fukuda, M. Isoflavone and Protein Constituents of Lactic Acid-Fermented Soy Milk Combine to Prevent Dyslipidemia in Rats Fed a High Cholesterol Diet. Nutrients 2014, 6, 5704-5723.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top