Next Article in Journal
Nutrigenetics and Nutrigenomics Insights into Diabetes Etiopathogenesis
Previous Article in Journal
Food Addiction and Its Impact on Weight-Based Stigma and the Treatment of Obese Individuals in the U.S. and Australia
Article Menu

Export Article

Open AccessArticle
Nutrients 2014, 6(11), 5327-5337;

Antioxidant and Antifatigue Activities of Polygonatum Alte-lobatum Hayata Rhizomes in Rats

Department of Ophthalmology and Medical Education Center, Kaohsiung Armed Force General Hospital, Kaohsiung 80284, Taiwan
Institute of Biochemistry and Biotechnology, Chung Shan Medical University and Chung Shan Medical University Hospital, Taichung City 40201, Taiwan
Department of Pharmacy & Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 90741, Taiwan
Graduate Institute of Sports Science, National Taiwan Sport University, Taoyuan 33301, Taiwan
Authors to whom correspondence should be addressed.
Received: 26 September 2014 / Revised: 22 October 2014 / Accepted: 28 October 2014 / Published: 21 November 2014
View Full-Text   |   Download PDF [146 KB, uploaded 21 November 2014]   |  


Polygonatum alte-lobatum Hayata, a rhizomatous perennial herb, belongs to the Liliaceae family and is endemic to Taiwan. We investigated the antioxidant and anti-fatigue activities of P. alte-lobatum in exercised rats. Levels of polyphenols, flavonoids and polysaccharides and 2,2-diphenyl-1-picrylhydrazyl (DPPH) free-radical scavenging activity were measured in extracts of P. alte-lobatum (EPA). Sprague-Dawley rats were randomly divided into four groups for 8-week treatment with vehicle (control) and low-, medium-, and high-dose EPA (LEPA, MEPA, HEPA; 0, 75, 150, and 375 mg/kg/day, respectively). Exercise performance was evaluated by exhaustive treadmill exercise time and by changes in body composition and biochemical variables at the end of the experiment. EPA contained polyphenols, flavonoids and polysaccharides, with polysaccharide content at least 26 times greater than that of polyphenols and flavonoids. Trend analysis revealed that EPA dose-dependently scavenged DPPH free radicals. EPA treatment dose-dependently increased endurance running time to exhaustion and superoxide dismutase activity and total antioxidant ability of blood. EPA dose-dependently decreased serum urea nitrogen and malondialdehyde levels after exercise. Hepatic glycogen content, an important energy source for exercise, was significantly increased with EPA treatment. EPA could be a potential agent with an anti-fatigue pharmacological function. View Full-Text
Keywords: Polygonatum alte-lobatum Hayata; antioxidant; anti-fatigue; biochemical parameters; exercised rats Polygonatum alte-lobatum Hayata; antioxidant; anti-fatigue; biochemical parameters; exercised rats

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Horng, C.-T.; Huang, J.-K.; Wang, H.-Y.; Huang, C.-C.; Chen, F.-A. Antioxidant and Antifatigue Activities of Polygonatum Alte-lobatum Hayata Rhizomes in Rats. Nutrients 2014, 6, 5327-5337.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top