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Nutrients 2014, 6(11), 4760-4793; doi:10.3390/nu6114760

n-3 Polyunsaturated Fatty Acids and Mechanisms to Mitigate Inflammatory Paracrine Signaling in Obesity-Associated Breast Cancer

1
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada
2
Guelph Food Research Centre, Agriculture and Agri-Food Canada, Guelph, ON N1G 5C9, Canada
3
Institut Curie, Paris 75248, France
*
Author to whom correspondence should be addressed.
Received: 2 September 2014 / Revised: 8 October 2014 / Accepted: 10 October 2014 / Published: 30 October 2014
(This article belongs to the Special Issue Nutrition and Cancer)
View Full-Text   |   Download PDF [316 KB, uploaded 30 October 2014]   |  

Abstract

Globally, the prevalence of obesity is increasing which subsequently increases the risk of the development of obesity-related chronic diseases. Low-grade chronic inflammation and dysregulated adipose tissue inflammatory mediator/adipokine secretion are well-established in obesity, and these factors increase the risk of developing inflammation-associated cancer. Breast cancer is of particular interest given that increased inflammation within the subcutaneous mammary adipose tissue depot can alter the local tissue inflammatory microenvironment such that it resembles that of obese visceral adipose tissue. Therefore, in obese women with breast cancer, increased inflammatory mediators both locally and systemically can perpetuate inflammation-associated pro-carcinogenic signaling pathways, thereby increasing disease severity. Herein, we discuss some of these inflammation-associated pro-carcinogenic mechanisms of the combined obese breast cancer phenotype and offer evidence that dietary long chain n-3 polyunsaturated fatty acids (PUFA) may have utility in mitigating the severity of obesity-associated inflammation and breast cancer. View Full-Text
Keywords: breast cancer; inflammation; obesity; adipokines; n-3 polyunsaturated fatty acids; leptin; adiponectin; aromatase; lipid rafts; eicosanoids breast cancer; inflammation; obesity; adipokines; n-3 polyunsaturated fatty acids; leptin; adiponectin; aromatase; lipid rafts; eicosanoids
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Monk, J.M.; Turk, H.F.; Liddle, D.M.; De Boer, A.A.; Power, K.A.; Ma, D.W.; Robinson, L.E. n-3 Polyunsaturated Fatty Acids and Mechanisms to Mitigate Inflammatory Paracrine Signaling in Obesity-Associated Breast Cancer. Nutrients 2014, 6, 4760-4793.

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