Next Article in Journal
Effects of Dietary Fat and Saturated Fat Content on Liver Fat and Markers of Oxidative Stress in Overweight/Obese Men and Women under Weight-Stable Conditions
Previous Article in Journal
Measuring Population Sodium Intake: A Review of Methods
Article Menu

Export Article

Open AccessArticle
Nutrients 2014, 6(11), 4663-4677; doi:10.3390/nu6114663

Codonopsis lanceolata Extract Prevents Diet-Induced Obesity in C57BL/6 Mice

1
Department of Food Science and Biotechnology, Kangwon National University, Chuncheon 200-701, Korea
2
Department of Nutrition and Food Science, College of Agriculture and Natural Resources, University of Maryland, College Park, MD 20742, USA
3
Hurum Central Research Institute, Ochang 363-883, Korea
4
Department of Food Science and Biotechnology, CHA University, Seongnam 463-836, Korea
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 9 July 2014 / Revised: 4 August 2014 / Accepted: 15 October 2014 / Published: 28 October 2014
View Full-Text   |   Download PDF [990 KB, uploaded 28 October 2014]   |  

Abstract

Codonopsis lanceolata extract (CLE) has been used in traditional medicine in the Asian-Pacific region for the treatment of bronchitis, cough, and inflammation. However, it is still unclear whether obesity in mice can be altered by diet supplementation with CLE. To investigate whether CLE could have preventative effects on high fat diet (HFD)-induced obesity, male C57BL/6 mice were placed on either a normal chow diet, 60% HFD, or a HFD supplemented with CLE (60, 180, and 360 mg/kg/day) for 12 weeks. CLE decreased body weight and subcutaneous and visceral fat weights in HFD-induced obese mice. CLE group mice showed lower fat accumulation and a smaller adipocyte area in the adipose tissue compared with the HFD group mice. CLE group mice exhibited lower serum levels of triglycerides, total cholesterol, low density lipoprotein (LDL), glucose, and insulin compared with the HFD group mice. In addition, CLE decreased liver weight and lowered the increase in aspartate aminotransferase (AST) and alanine transaminase (ALT) levels in HFD-induced obese mice. These results indicate that CLE can inhibit the development of diet-induced obesity and hyperlipidemia in C57BL/6 mice. View Full-Text
Keywords: obesity; Codonopsis lanceolata; body weight; cholesterol; triglyceride obesity; Codonopsis lanceolata; body weight; cholesterol; triglyceride
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Lee, J.S.; Kim, K.-J.; Kim, Y.-H.; Kim, D.-B.; Shin, G.-H.; Cho, J.-H.; Kim, B.K.; Lee, B.-Y.; Lee, O.-H. Codonopsis lanceolata Extract Prevents Diet-Induced Obesity in C57BL/6 Mice. Nutrients 2014, 6, 4663-4677.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top