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Nutrients 2014, 6(10), 4373-4388; doi:10.3390/nu6104373

25-Hydroxyvitamin D and Its Relationship with Autonomic Dysfunction Using Time- and Frequency-Domain Parameters of Heart Rate Variability in Korean Populations: A Cross-Sectional Study

1
Department of Family Medicine, Pusan National University School of Medicine, 602-739 Busan, Korea
2
Biomedical Research Institute, Pusan National University Hospital, 602-739 Busan, Korea
3
Medical Education Unit and Medical Research Institute, Pusan National University School of Medicine, 626-870 Yangsan, Korea
4
Family Medicine Clinic and Research Institute of Convergence of Biomedical Science and Technology, Pusan National Yangsan Hospital, 626-789 Yangsan, Korea
5
Department of Preventive Medicine and Occupational Medicine, Pusan National University School of Medicine, 626-770 Yangsan, Korea
*
Author to whom correspondence should be addressed.
Received: 30 July 2014 / Revised: 28 August 2014 / Accepted: 24 September 2014 / Published: 16 October 2014
(This article belongs to the Special Issue Nutrition and CVD)
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Abstract

Previous studies have demonstrated that reduced heart rate variability (HRV) and hypovitaminosis D are associated with cardiovascular disease (CVD). However, few reports have investigated the effects of vitamin D on HRV. This cross-sectional study analyzed serum 25-hydroxyvitamin D (25(OH)D) and HRV indices using 5-min R-R interval recordings with an automatic three-channel electrocardiography in healthy subjects (103 males and 73 females). Standard deviation of N-N interval (SDNN), square root of mean squared differences of successive N-N intervals (RMSSD), total power (TP), very low frequency (VLF), low frequency (LF), and high frequency (HF) were reported. The mean age of subjects was 55.3 ± 11.3 years and the mean 25(OH)D level was 21.2 ± 9.9 ng/mL. In a multiple linear regression model, 25(OH)D was positively correlated with SDNN (β = 0.240, p < 0.002), and LF (β = 0.144, p = 0.044). Vitamin D deficiency (25(OH)D < 15 ng/mL) was associated with decreased SDNN (<30 m/s) (OR, 3.07; 95% confidence interval (CI), 1.32–7.14; p = 0.014) after adjusting for covariates. We found that lower 25(OH)D levels were associated with lower HRV, suggesting a possible explanation for the higher risk of CVD in populations with hypovitaminosis D. View Full-Text
Keywords: heart rate variability; vitamin D; 25-hydroxyvitamin D heart rate variability; vitamin D; 25-hydroxyvitamin D
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Tak, Y.J.; Lee, J.G.; Kim, Y.J.; Lee, S.Y.; Cho, B.M. 25-Hydroxyvitamin D and Its Relationship with Autonomic Dysfunction Using Time- and Frequency-Domain Parameters of Heart Rate Variability in Korean Populations: A Cross-Sectional Study. Nutrients 2014, 6, 4373-4388.

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