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Nutrients 2013, 5(9), 3696-3712; doi:10.3390/nu5093696

Lycopene Supplement and Blood Pressure: An Updated Meta-Analysis of Intervention Trials

1,†,*  and 2,†
1 School of Public Health, Medical College of Soochow University, Suzhou 215123, China 2 Department of Radiotherapy, the First Affiliated Hospital of Soochow University, Suzhou 215006, China These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 19 July 2013 / Revised: 9 September 2013 / Accepted: 12 September 2013 / Published: 18 September 2013
(This article belongs to the Special Issue Vitamin A and Carotenoids)
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Epidemiological studies suggested that lycopene supplement could decrease blood pressure, but the results were conflicting. We conducted an updated meta-analysis by screening PubMed databases, and calculated the combined effect size using a random effect model. In addition, subgroup analysis stratified by baseline blood pressure, lycopene dosage, duration, study location and the funding support of the paper was also conducted. Six studies met our inclusion criteria, and the pooled analysis demonstrated a significant reduction of systolic blood pressure (SBP) (mean SBP = −4.953 [−8.820, −1.086], p = 0.012) with obvious heterogeneity (p = 0.034, I2 = 58.5%). Subgroup analysis results showed that higher dosage of lycopene supplement (>12 mg/day) could lower SBP more significantly, especially for participants with baseline SBP >120 mmHg, or Asians, while lycopene intervention had no statistical effect on diastolic blood pressure (DBP) (mean DBP = −3.809 [−8.177, 0.560], p = 0.087), and obvious heterogeneity was also observed (p = 0.074, I2 = 53.1%). Our present study suggests that lycopene supplement >12 mg/day might effectively decrease SBP, particularly among Asians or population with higher baseline SBP.
Keywords: lycopene; blood pressure; intervention trials; meta-analysis lycopene; blood pressure; intervention trials; meta-analysis
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Li, X.; Xu, J. Lycopene Supplement and Blood Pressure: An Updated Meta-Analysis of Intervention Trials. Nutrients 2013, 5, 3696-3712.

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