Nutrients 2013, 5(7), 2314-2332; doi:10.3390/nu5072314
Review

Modulation of Immune Function by Polyphenols: Possible Contribution of Epigenetic Factors

1,†email, 1,†email, 1email and 2,* email
Received: 4 April 2013; in revised form: 15 May 2013 / Accepted: 26 May 2013 / Published: 28 June 2013
(This article belongs to the Special Issue Nutrients and Immune Function)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Several biological activities have been described for polyphenolic compounds, including a modulator effect on the immune system. The effects of these biologically active compounds on the immune system are associated to processes as differentiation and activation of immune cells. Among the mechanisms associated to immune regulation are epigenetic modifications as DNA methylation of regulatory sequences, histone modifications and posttranscriptional repression by microRNAs that influences the gene expression of key players involved in the immune response. Considering that polyphenols are able to regulate the immune function and has been also demonstrated an effect on epigenetic mechanisms, it is possible to hypothesize that there exists a mediator role of epigenetic mechanisms in the modulation of the immune response by polyphenols.
Keywords: polyphenols; immune system; epigenetic
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MDPI and ACS Style

Cuevas, A.; Saavedra, N.; Salazar, L.A.; Abdalla, D.S.P. Modulation of Immune Function by Polyphenols: Possible Contribution of Epigenetic Factors. Nutrients 2013, 5, 2314-2332.

AMA Style

Cuevas A, Saavedra N, Salazar LA, Abdalla DSP. Modulation of Immune Function by Polyphenols: Possible Contribution of Epigenetic Factors. Nutrients. 2013; 5(7):2314-2332.

Chicago/Turabian Style

Cuevas, Alejandro; Saavedra, Nicolás; Salazar, Luis A.; Abdalla, Dulcineia S.P. 2013. "Modulation of Immune Function by Polyphenols: Possible Contribution of Epigenetic Factors." Nutrients 5, no. 7: 2314-2332.

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