Nutrients 2013, 5(6), 1937-1948; doi:10.3390/nu5061937
Review

The Relationship between Selenoprotein P and Glucose Metabolism in Experimental Studies

email and * email
Received: 26 February 2013; in revised form: 30 April 2013 / Accepted: 6 May 2013 / Published: 29 May 2013
(This article belongs to the Special Issue Dietary Selenium and Health)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Selenium is an essential trace element in the diet of mammals which is important for many physiological functions. However, a number of epidemiological studies have suggested that high selenium status is a possible risk factor for the development of type 2 diabetes, although they cannot distinguish between cause and effect. Selenoprotein P (Sepp1) is central to selenium homeostasis and widely expressed in the organism. Here we review the interaction between Sepp1 and glucose metabolism with an emphasis on experimental evidence. In models with or without gene modification, glucose and insulin can regulate Sepp1 expression in the pancreas and liver, and vice versa. Especially in the liver, Sepp1 is regulated virtually like a gluconeogenic enzyme. Combining these data suggests that there could be a feedback regulation between hepatic Sepp1 and pancreatic insulin and that increasing circulating Sepp1 might be the result rather than the cause of abnormal glucose metabolism. Future studies specifically designed to overexpress Sepp1 are needed in order to provide a more robust link between Sepp1 and type 2 diabetes.
Keywords: selenium; selenoprotein P; glucose metabolism; insulin; gene expression
PDF Full-text Download PDF Full-Text [203 KB, uploaded 29 May 2013 11:09 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Mao, J.; Teng, W. The Relationship between Selenoprotein P and Glucose Metabolism in Experimental Studies. Nutrients 2013, 5, 1937-1948.

AMA Style

Mao J, Teng W. The Relationship between Selenoprotein P and Glucose Metabolism in Experimental Studies. Nutrients. 2013; 5(6):1937-1948.

Chicago/Turabian Style

Mao, Jinyuan; Teng, Weiping. 2013. "The Relationship between Selenoprotein P and Glucose Metabolism in Experimental Studies." Nutrients 5, no. 6: 1937-1948.

Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert