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The Relationship between Selenoprotein P and Glucose Metabolism in Experimental Studies
Liaoning Provincial Key Laboratory of Endocrine Diseases, Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, No.155, North Nanjing Street, Shenyang 110001, China
* Author to whom correspondence should be addressed.
Received: 26 February 2013; in revised form: 30 April 2013 / Accepted: 6 May 2013 / Published: 29 May 2013
Abstract: Selenium is an essential trace element in the diet of mammals which is important for many physiological functions. However, a number of epidemiological studies have suggested that high selenium status is a possible risk factor for the development of type 2 diabetes, although they cannot distinguish between cause and effect. Selenoprotein P (Sepp1) is central to selenium homeostasis and widely expressed in the organism. Here we review the interaction between Sepp1 and glucose metabolism with an emphasis on experimental evidence. In models with or without gene modification, glucose and insulin can regulate Sepp1 expression in the pancreas and liver, and vice versa. Especially in the liver, Sepp1 is regulated virtually like a gluconeogenic enzyme. Combining these data suggests that there could be a feedback regulation between hepatic Sepp1 and pancreatic insulin and that increasing circulating Sepp1 might be the result rather than the cause of abnormal glucose metabolism. Future studies specifically designed to overexpress Sepp1 are needed in order to provide a more robust link between Sepp1 and type 2 diabetes.
Keywords: selenium; selenoprotein P; glucose metabolism; insulin; gene expression
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MDPI and ACS Style
Mao, J.; Teng, W. The Relationship between Selenoprotein P and Glucose Metabolism in Experimental Studies. Nutrients 2013, 5, 1937-1948.
Mao J, Teng W. The Relationship between Selenoprotein P and Glucose Metabolism in Experimental Studies. Nutrients. 2013; 5(6):1937-1948.
Mao, Jinyuan; Teng, Weiping. 2013. "The Relationship between Selenoprotein P and Glucose Metabolism in Experimental Studies." Nutrients 5, no. 6: 1937-1948.