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Selenium Metabolism in Cancer Cells: The Combined Application of XAS and XFM Techniques to the Problem of Selenium Speciation in Biological Systems
Nutrients 2013, 5(6), 1937-1948; doi:10.3390/nu5061937

The Relationship between Selenoprotein P and Glucose Metabolism in Experimental Studies

Liaoning Provincial Key Laboratory of Endocrine Diseases, Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University, No.155, North Nanjing Street, Shenyang 110001, China
* Author to whom correspondence should be addressed.
Received: 26 February 2013 / Revised: 30 April 2013 / Accepted: 6 May 2013 / Published: 29 May 2013
(This article belongs to the Special Issue Dietary Selenium and Health)
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Selenium is an essential trace element in the diet of mammals which is important for many physiological functions. However, a number of epidemiological studies have suggested that high selenium status is a possible risk factor for the development of type 2 diabetes, although they cannot distinguish between cause and effect. Selenoprotein P (Sepp1) is central to selenium homeostasis and widely expressed in the organism. Here we review the interaction between Sepp1 and glucose metabolism with an emphasis on experimental evidence. In models with or without gene modification, glucose and insulin can regulate Sepp1 expression in the pancreas and liver, and vice versa. Especially in the liver, Sepp1 is regulated virtually like a gluconeogenic enzyme. Combining these data suggests that there could be a feedback regulation between hepatic Sepp1 and pancreatic insulin and that increasing circulating Sepp1 might be the result rather than the cause of abnormal glucose metabolism. Future studies specifically designed to overexpress Sepp1 are needed in order to provide a more robust link between Sepp1 and type 2 diabetes.
Keywords: selenium; selenoprotein P; glucose metabolism; insulin; gene expression selenium; selenoprotein P; glucose metabolism; insulin; gene expression
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Mao, J.; Teng, W. The Relationship between Selenoprotein P and Glucose Metabolism in Experimental Studies. Nutrients 2013, 5, 1937-1948.

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