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Nutrients 2013, 5(12), 4990-5011; doi:10.3390/nu5124990
Review

Dietary Magnesium and Genetic Interactions in Diabetes and Related Risk Factors: A Brief Overview of Current Knowledge

1
, 2
, 3
 and 4,5,*
1 Department of Nutrition, Harvard School of Public Health, 677 Huntington Avenue, Building 2, Boston, MA 02115, USA 2 Nutritional Epidemiology Program, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, 9th Floor, Boston, MA 02111, USA 3 Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, 714 N. Senate Avenue, Indianapolis, IN 46202, USA 4 Division of Aging, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 1620 Tremont Street, 3rd Floor, Boston, MA 02120, USA 5 Boston Veterans Affairs Healthcare System, Boston, MA 02130, USA
* Author to whom correspondence should be addressed.
Received: 17 October 2013 / Revised: 18 November 2013 / Accepted: 27 November 2013 / Published: 6 December 2013
(This article belongs to the Special Issue Dietary Magnesium and Human Health)
View Full-Text   |   Download PDF [237 KB, uploaded 6 December 2013]

Abstract

Nutritional genomics has exploded in the last decade, yielding insights—both nutrigenomic and nutrigenetic—into the physiology of dietary interactions and our genes. Among these are insights into the regulation of magnesium transport and homeostasis and mechanisms underlying magnesium’s role in insulin and glucose handling. Recent observational evidence has attempted to examine some promising research avenues on interaction between genetics and dietary magnesium in relation to diabetes and diabetes risk factors. This brief review summarizes the recent evidence on dietary magnesium’s role in diabetes and related traits in the presence of underlying genetic risk, and discusses future potential research directions.
Keywords: magnesium; diet; genetic interaction; genome-wide interaction study; diabetes; glucose; insulin magnesium; diet; genetic interaction; genome-wide interaction study; diabetes; glucose; insulin
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Hruby, A.; McKeown, N.M.; Song, Y.; Djoussé, L. Dietary Magnesium and Genetic Interactions in Diabetes and Related Risk Factors: A Brief Overview of Current Knowledge. Nutrients 2013, 5, 4990-5011.

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