Nutrients 2013, 5(11), 4760-4775; doi:10.3390/nu5114760
Review

Folate Deficiency and Folic Acid Supplementation: The Prevention of Neural-Tube Defects and Congenital Heart Defects

Received: 4 October 2013; in revised form: 2 November 2013 / Accepted: 5 November 2013 / Published: 21 November 2013
(This article belongs to the Special Issue Folate Metabolism and Nutrition)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Diet, particularly vitamin deficiency, is associated with the risk of birth defects. The aim of this review paper is to show the characteristics of common and severe neural-tube defects together with congenital heart defects (CHD) as vitamin deficiencies play a role in their origin. The findings of the Hungarian intervention (randomized double-blind and cohort controlled) trials indicated that periconceptional folic acid (FA)-containing multivitamin supplementation prevented the major proportion (about 90%) of neural-tube defects (NTD) as well as a certain proportion (about 40%) of congenital heart defects. Finally the benefits and drawbacks of three main practical applications of folic acid/multivitamin treatment such as (i) dietary intake; (ii) periconceptional supplementation; and (iii) flour fortification are discussed. The conclusion arrived at is indeed confirmation of Benjamin Franklin’s statement: “An ounce of prevention is better than a pound of care”.
Keywords: neural-tube defects; congenital heart defects; folic acid; multivitamins; primary prevention
PDF Full-text Download PDF Full-Text [210 KB, uploaded 21 November 2013 12:12 CET]

Export to BibTeX |
EndNote


MDPI and ACS Style

Czeizel, A.E.; Dudás, I.; Vereczkey, A.; Bánhidy, F. Folate Deficiency and Folic Acid Supplementation: The Prevention of Neural-Tube Defects and Congenital Heart Defects. Nutrients 2013, 5, 4760-4775.

AMA Style

Czeizel AE, Dudás I, Vereczkey A, Bánhidy F. Folate Deficiency and Folic Acid Supplementation: The Prevention of Neural-Tube Defects and Congenital Heart Defects. Nutrients. 2013; 5(11):4760-4775.

Chicago/Turabian Style

Czeizel, Andrew E.; Dudás, Istvan; Vereczkey, Attila; Bánhidy, Ferenc. 2013. "Folate Deficiency and Folic Acid Supplementation: The Prevention of Neural-Tube Defects and Congenital Heart Defects." Nutrients 5, no. 11: 4760-4775.

Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert