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Nutrients 2012, 4(8), 1137-1150; doi:10.3390/nu4081137

Fructose Rich Diet-Induced High Plasminogen Activator Inhibitor-1 (PAI-1) Production in the Adult Female Rat: Protective Effect of Progesterone

Neuroendocrine Unit, IMBICE (CONICET-CICPBA), 1900 La Plata, Argentina
Division of Endocrinology, University Hospital (CHUV), CH 1011 Lausanne, Switzerland
Deceased on 17 November 2011.
Author to whom correspondence should be addressed.
Received: 24 May 2012 / Revised: 20 July 2012 / Accepted: 8 August 2012 / Published: 22 August 2012
(This article belongs to the Special Issue Nutrigenetics and Nutrigenomics)
View Full-Text   |   Download PDF [243 KB, uploaded 23 August 2012]   |  


The effect of progesterone (P4) on fructose rich diet (FRD) intake-induced metabolic, endocrine and parametrial adipose tissue (PMAT) dysfunctions was studied in the adult female rat. Sixty day-old rats were i.m. treated with oil alone (control, CT) or containing P4 (12 mg/kg). Rats ate Purina chow-diet ad libitum throughout the entire experiment and, between 100 and 120 days of age drank ad libitum tap water alone (normal diet; CT-ND and P4-ND) or containing fructose (10% w/v; CT-FRD and P4-FRD). At age 120 days, animals were subjected to a glucose tolerance test or decapitated. Plasma concentrations of various biomarkers and PMAT gene abundance were monitored. P4-ND (vs. CT-ND) rats showed elevated circulating levels of lipids. CT-FRD rats displayed high (vs. CT-ND) plasma concentrations of lipids, leptin, adiponectin and plasminogen activator inhibitor-1 (PAI-1). Lipidemia and adiponectinemia were high (vs. P4-ND) in P4-FRD rats. Although P4 failed to prevent FRD-induced hyperleptinemia, it was fully protective on FRD-enhanced plasma PAI-1 levels. PMAT leptin and adiponectin mRNAs were high in CT-FRD and P4-FRD rats. While FRD enhanced PMAT PAI-1 mRNA abundance in CT rats, this effect was absent in P4 rats. Our study supports that a preceding P4-enriched milieu prevented the enhanced prothrombotic risk induced by FRD-elicited high PAI-1 production. View Full-Text
Keywords: high carbohydrate diet; glucose tolerance; insulin; adipokines; allostasis high carbohydrate diet; glucose tolerance; insulin; adipokines; allostasis

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MDPI and ACS Style

Castrogiovanni, D.; Alzamendi, A.; Ongaro, L.; Giovambattista, A.; Gaillard, R.C.; Spinedi, E. Fructose Rich Diet-Induced High Plasminogen Activator Inhibitor-1 (PAI-1) Production in the Adult Female Rat: Protective Effect of Progesterone. Nutrients 2012, 4, 1137-1150.

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