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Nutrients 2012, 4(4), 243-257; doi:10.3390/nu4040243
Review

Celiac Disease, Inflammation and Oxidative Damage: A Nutrigenetic Approach

1
, 2
, 2
 and 3,*
Received: 23 November 2011; in revised form: 2 March 2012 / Accepted: 16 March 2012 / Published: 27 March 2012
(This article belongs to the Special Issue Foodomics 2011)
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Abstract: Celiac disease (CD), a common heritable chronic inflammatory condition of the small intestine caused by permanent intolerance to gluten/gliadin (prolamin), is characterized by a complex interplay between genetic and environmental factors. Developments in proteomics have provided an important contribution to the understanding of the biochemical and immunological aspects of the disease and the mechanisms involved in toxicity of prolamins. It has been demonstrated that some gliadin peptides resistant to complete proteolytic digestion may directly affect intestinal cell structure and functions by modulating gene expression and oxidative stress. In recent years, the creation of the two research fields Nutrigenomics and Nutrigenetics, has enabled the elucidation of some interactions between diet, nutrients and genes. Various dietary components including long chain ω-3 fatty acids, plant flavonoids, and carotenoids have been demonstrated to modulate oxidative stress, gene expression and production of inflammatory mediators. Therefore their adoption could preserve intestinal barrier integrity, play a protective role against toxicity of gliadin peptides and have a role in nutritional therapy of celiac disease.
Keywords: celiac disease; gliadin peptides; nutrigenetic; nutrigenomic; proteomic; fitonutrients; oxidative stress; inflammation celiac disease; gliadin peptides; nutrigenetic; nutrigenomic; proteomic; fitonutrients; oxidative stress; inflammation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Ferretti, G.; Bacchetti, T.; Masciangelo, S.; Saturni, L. Celiac Disease, Inflammation and Oxidative Damage: A Nutrigenetic Approach. Nutrients 2012, 4, 243-257.

AMA Style

Ferretti G, Bacchetti T, Masciangelo S, Saturni L. Celiac Disease, Inflammation and Oxidative Damage: A Nutrigenetic Approach. Nutrients. 2012; 4(4):243-257.

Chicago/Turabian Style

Ferretti, Gianna; Bacchetti, Tiziana; Masciangelo, Simona; Saturni, Letizia. 2012. "Celiac Disease, Inflammation and Oxidative Damage: A Nutrigenetic Approach." Nutrients 4, no. 4: 243-257.



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