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A correction was published on 13 April 2010, see Nutrients 2010, 2(4), 481.

Nutrients 2010, 2(3), 319-329; doi:10.3390/nu2030319

The Effect of Antioxidant Supplementation on Fatigue during Exercise: Potential Role for NAD+(H)

Received: 19 January 2010 / Revised: 9 February 2010 / Accepted: 5 March 2010 / Published: 10 March 2010
(This article belongs to the Special Issue Sports Nutrition)
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This study compared serum pyridine levels (NAD+ /NADH) in trained (n = 6) and untrained (n = 7) subjects after continuous progressive exercise at 50%, 70% then 95% of physical work capacity until fatigue (TTF) after consuming a placebo or antioxidant (AO) cocktail (Lactaway©). An increase of 17% in TTF was observed in AO as compared to placebo (p = 0.032). This was accompanied by a significant increase in serum NAD+ levels (p = 0.037) in the AO supplemented group post exercise. The increases in NAD+ and improved endurance reflect lower oxidative stress-induced suppression of aerobic respiration.
Keywords: NAD+; NADH; exercise; oxidative stress; antioxidant NAD+; NADH; exercise; oxidative stress; antioxidant
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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Mach, J.; Midgley, A.W.; Dank, S.; Grant, R.S.; Bentley, D.J. The Effect of Antioxidant Supplementation on Fatigue during Exercise: Potential Role for NAD+(H). Nutrients 2010, 2, 319-329.

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