Nutrients 2010, 2(3), 319-329; doi:10.3390/nu2030319
Article

The Effect of Antioxidant Supplementation on Fatigue during Exercise: Potential Role for NAD+(H)

John Mach 1 email, Adrian W. Midgley 2 email, Steve Dank 3 email, Ross S. Grant 1,4 email and David J. Bentley 5,* email
1 School of Medical Science, University of New South Wales, Kensington, 2052, Australia 2 Department of Sport, Health and Exercise Science, University of Hull, Hull, HU6 7RX, UK 3 Department of Pharmacology, University of Sydney, Sydney, 2006, Australia 4 Australasian Research Institute, Sydney Adventist Hospital, Sydney, 2076 Australia 5 Health and Exercise Science, University of New South Wales, Kensington, 2052 Australia
* Author to whom correspondence should be addressed.
Received: 19 January 2010; in revised form: 9 February 2010 / Accepted: 5 March 2010 / Published: 10 March 2010
(This article belongs to the Special Issue Sports Nutrition)
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Abstract: This study compared serum pyridine levels (NAD+ /NADH) in trained (n = 6) and untrained (n = 7) subjects after continuous progressive exercise at 50%, 70% then 95% of physical work capacity until fatigue (TTF) after consuming a placebo or antioxidant (AO) cocktail (Lactaway©). An increase of 17% in TTF was observed in AO as compared to placebo (p = 0.032). This was accompanied by a significant increase in serum NAD+ levels (p = 0.037) in the AO supplemented group post exercise. The increases in NAD+ and improved endurance reflect lower oxidative stress-induced suppression of aerobic respiration.
Keywords: NAD+; NADH; exercise; oxidative stress; antioxidant

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Cite This Article

MDPI and ACS Style

Mach, J.; Midgley, A.W.; Dank, S.; Grant, R.S.; Bentley, D.J. The Effect of Antioxidant Supplementation on Fatigue during Exercise: Potential Role for NAD+(H). Nutrients 2010, 2, 319-329.

AMA Style

Mach J, Midgley AW, Dank S, Grant RS, Bentley DJ. The Effect of Antioxidant Supplementation on Fatigue during Exercise: Potential Role for NAD+(H). Nutrients. 2010; 2(3):319-329.

Chicago/Turabian Style

Mach, John; Midgley, Adrian W.; Dank, Steve; Grant, Ross S.; Bentley, David J. 2010. "The Effect of Antioxidant Supplementation on Fatigue during Exercise: Potential Role for NAD+(H)." Nutrients 2, no. 3: 319-329.

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