Status of Retinoids and Carotenoids and Associations with Clinical Outcomes in Maternal-Infant Pairs in Nigeria
AbstractVitamin A is an essential nutrient in pregnancy, and other carotenoids have been independently associated with maternal-infant outcomes. The objective of this study was to quantify the status of vitamin A and carotenoids in Nigerian maternal-infant pairs at delivery, compare these to a cohort from a developed nation, and determine the impact on clinical outcomes. Maternal and cord blood samples were collected in 99 Nigerian mother-infant pairs. Concentrations of lutein + zeaxanthin, β-cryptoxanthin, lycopene, α- and β-carotenes, and retinol were measured using HPLC. Descriptive statistics were calculated and Spearman coefficients were used to assess correlations between maternal and cord measurements; Mann-Whitney tests were used to compare median plasma values between dichotomous variables. Linear regression models were used to adjust for relevant confounders. A p < 0.05 was considered statistically significant. Thirty-five percent of mothers had plasma retinol concentrations ≤0.70 µmol/L; 82% of infants had plasma retinol concentrations ≤0.70 µmol/L at delivery. Maternal and infant concentrations of vitamin A compounds were highly correlated and were associated with newborn growth and Apgar scores. Despite plasma concentrations of pro-vitamin A carotenoids higher than those reported in other populations, pregnant Nigerian women have a high prevalence of vitamin A deficiency. As vitamin A related compounds are modifiable by diet, future research determining the clinical impact of these compounds is warranted. View Full-Text
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Hanson, C.; Lyden, E.; Anderson-Berry, A.; Kocmich, N.; Rezac, A.; Delair, S.; Furtado, J.; Van Ormer, M.; Izevbigie, N.; Olateju, E.; Adaba, G.; Anigilaje, E.; Tahiru, T.; Obaro, S. Status of Retinoids and Carotenoids and Associations with Clinical Outcomes in Maternal-Infant Pairs in Nigeria. Nutrients 2018, 10, 1286.
Hanson C, Lyden E, Anderson-Berry A, Kocmich N, Rezac A, Delair S, Furtado J, Van Ormer M, Izevbigie N, Olateju E, Adaba G, Anigilaje E, Tahiru T, Obaro S. Status of Retinoids and Carotenoids and Associations with Clinical Outcomes in Maternal-Infant Pairs in Nigeria. Nutrients. 2018; 10(9):1286.Chicago/Turabian Style
Hanson, Corrine; Lyden, Elizabeth; Anderson-Berry, Ann; Kocmich, Nicholas; Rezac, Amy; Delair, Shirley; Furtado, Jeremy; Van Ormer, Matthew; Izevbigie, NI; Olateju, EK; Adaba, GA; Anigilaje, EA; Tahiru, Tahiru; Obaro, Stephen. 2018. "Status of Retinoids and Carotenoids and Associations with Clinical Outcomes in Maternal-Infant Pairs in Nigeria." Nutrients 10, no. 9: 1286.
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