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Nutrients 2018, 10(9), 1282; https://doi.org/10.3390/nu10091282

Preconception Micronutrient Supplementation Reduced Circulating Branched Chain Amino Acids at 12 Weeks Gestation in an Open Trial of Guatemalan Women Who Are Overweight or Obese

1
Section of Nutrition, Department of Pediatrics, School of Medicine, University of Colorado, Aurora, CO 80045, USA
2
Section of Clinical Genetics and Metabolism, Department of Pediatrics, School of Medicine, University of Colorado, Aurora, CO 80045, USA
3
School of Medicine, University of Oklahoma, Tulsa, OK 74135, USA
4
Division of Endocrinology, Metabolism, & Diabetes, Department of Medicine, School of Medicine, University of Colorado, Aurora, CO 80045, USA
5
School of School of Nursing, University of Colorado, Aurora, CO 80045, USA
6
Maternal and Infant Health Department, Institute of Nutrition of Central American and Panama, Guatemala 1188, Guatemala
7
Section of Neonatology, Department of Pediatrics, School of Medicine, University of Colorado, Aurora, CO 80045, USA
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 12 July 2018 / Revised: 4 September 2018 / Accepted: 6 September 2018 / Published: 11 September 2018
(This article belongs to the Special Issue Nutrient Requirements and Dietary Intakes of Women during Pregnancy)
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Abstract

Elevated branched chain amino acids (BCAAs: valine, leucine, and isoleucine) are well-established biomarkers of obesity-associated insulin resistance (IR). Mounting evidence suggests that low- and middle-income countries are suffering from a “double burden” of both undernutrition (growth stunting) and overnutrition (obesity) as these countries undergo a “nutrition transition”. The purpose of this study was to examine if pre-pregnancy body mass index (BMI, kg/m2) and a daily lipid-based micronutrient supplement (LNS, Nutriset) would lead to cross-sectional differences in circulating levels of branched chain amino acids (BCAAs) in Guatemalan women experiencing short stature during early pregnancy. Using data from an ongoing randomized controlled trial, Women First, we studied women who were normal weight (NW, BMI range for this cohort = 20.1–24.1 kg/m2) or overweight/obese (OW/OB, BMI range for this cohort = 25.6–31.9 kg/m2), and divided into two groups: those who received daily LNS ≥ 3 months prior to conception through 12 weeks gestation (+LNS), or no LNS (−LNS) (n = 9–10/group). BCAAs levels were obtained from dried blood spot card samples (DBS) assessed at 12 weeks gestation. DBS cards provide a stable, efficient, and reliable means of collecting, transporting, and storing blood samples in low resource or field settings. Circulating maternal leptin, adiponectin, and insulin were determined by immunoassays from serum samples collected at 12 weeks gestation. We found maternal pre-pregnancy body mass index (ppBMI) was associated with higher circulating BCAAs (r2 = 0.433, p = 0.002) and higher leptin/adiponectin ratio (r = 0.466, p = 0.044) in −LNS mothers at 12 weeks gestation. +LNS mothers demonstrated no correlations between BCAAs or leptin/adiponectin ratio across ppBMI suggesting LNS may be effective at improving metabolic status in OW/OB mothers during early pregnancy. View Full-Text
Keywords: branched chain amino acids; obesity; pregnancy; micronutrients; dried blood spot cards branched chain amino acids; obesity; pregnancy; micronutrients; dried blood spot cards
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Borengasser, S.J.; Baker, P.R., II; Kerns, M.E.; Miller, L.V.; Palacios, A.P.; Kemp, J.F.; Westcott, J.E.; Morrison, S.D.; Hernandez, T.L.; Garces, A.; Figueroa, L.; Friedman, J.E.; Hambidge, K.M.; Krebs, N.F. Preconception Micronutrient Supplementation Reduced Circulating Branched Chain Amino Acids at 12 Weeks Gestation in an Open Trial of Guatemalan Women Who Are Overweight or Obese. Nutrients 2018, 10, 1282.

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