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Nutrients 2018, 10(9), 1250; https://doi.org/10.3390/nu10091250

Short-Term Fish Oil Treatment Changes the Composition of Phospholipids While Not Affecting the Expression of Mfsd2a Omega-3 Transporter in the Brain and Liver of the 5xFAD Mouse Model of Alzheimer’s Disease

1
Department of Neurobiology, Institute for Biological Research, University of Belgrade, Bulevar despota Stefana 142, 11060 Belgrade, Serbia
2
Center of Excellence in Nutrition and Metabolism Research, CENM, Tadeusa Koscuska 1, 11000 Belgrade, Serbia
*
Authors to whom correspondence should be addressed.
Received: 4 July 2018 / Revised: 25 August 2018 / Accepted: 28 August 2018 / Published: 6 September 2018
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Abstract

Long-term fish oil (FO) supplementation is able to improve Alzheimer’s disease (AD) pathology. We aimed to determine the impact of short-term fish oil (FO) intake on phospholipids composition and plaque pathology in 5xFAD mice, a widely used animal model of AD. A 3-week-long FO supplementation administered at 3 months of age decreased the number of dense core plaques in the 5xFAD cortex and changed phospholipids in the livers and brains of wild-type (Wt) and 5xFAD mice. Livers of both genotypes responded by increase of n-3 and reciprocal decrease of n-6 fatty acids. In Wt brains, FO supplementation induced elevation of n-3 fatty acids and subsequent enhancement of n-6/n-3 ratio. However, in 5xFAD brains the improved n-6/n-3 ratio was mainly due to FO-induced decrease in arachidonic and adrenic n-6 fatty acids. Also, brain and liver abundance of n-3 fatty acids were strongly correlated in Wts, oppositely to 5xFADs where significant brain-liver correlation exists only for n-6 fatty acids. Expression of omega-3 transporter Mfs2a remained unchanged after FO supplementation. We have demonstrated that even a short-term FO intake improves the phospholipid composition and has a significant effect on plaque burden in 5xFAD brains when applied in early stages of AD pathology. View Full-Text
Keywords: Mfsd2a; docosahexaenoic acid; Alzheimer’s disease; n-3 polyunsaturated fatty acids; amyloid-β; n-6 fatty acids Mfsd2a; docosahexaenoic acid; Alzheimer’s disease; n-3 polyunsaturated fatty acids; amyloid-β; n-6 fatty acids
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Milanovic, D.; Petrovic, S.; Brkic, M.; Avramovic, V.; Perovic, M.; Ivkovic, S.; Glibetic, M.; Kanazir, S. Short-Term Fish Oil Treatment Changes the Composition of Phospholipids While Not Affecting the Expression of Mfsd2a Omega-3 Transporter in the Brain and Liver of the 5xFAD Mouse Model of Alzheimer’s Disease. Nutrients 2018, 10, 1250.

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