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Nutrients 2018, 10(8), 1026; https://doi.org/10.3390/nu10081026

Maternal Lipid Concentrations during Early Pregnancy and Eating Behaviour and Energy Intake in the Offspring

1
Department of Public Health—Amsterdam Public Health Research Institute, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
2
Department of Clinical Epidemiology, Biostatistics and Bioinformatics—Amsterdam Public Health Research Institute, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
3
Swammerdam Institute for Life Sciences, Centre for Neuroscience, University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The Netherlands
*
Author to whom correspondence should be addressed.
Received: 13 June 2018 / Revised: 25 July 2018 / Accepted: 3 August 2018 / Published: 6 August 2018
(This article belongs to the Special Issue Nutrient Requirements and Dietary Intakes of Women during Pregnancy)
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Abstract

Worldwide, childhood obesity is rapidly increasing, making it a pressing public health issue. Obesity is strongly linked to eating behaviour and energy intake but little is known about their prenatal determinants. In an exploratory study of data collected within the Amsterdam Born Children and their Development (ABCD) study, we hypothesized that intra-uterine exposure to increased lipids is associated with adverse eating behaviour and increased energy intake in the offspring at age 5. During early gestation, a non-fasting blood sample was taken from 1463 non-diabetic Dutch women, including: total cholesterol (TC), triglycerides (TG), free fatty acids (FFA), Apolipoprotein A1 (ApoA1) and Apolipoprotein B (ApoB). Eating behaviour, measured using the Children’s Eating Behaviour Questionnaire, included food approaching (enjoyment of food, food responsiveness) and food avoidant behaviour (satiety responsiveness, slowness of eating). Energy intake (total energy, fat and carbohydrate intake) was measured using a validated food frequency questionnaire. Associations were analysed using multivariable linear regression. Increased maternal TC concentrations were associated with lower enjoyment of food, higher satiety responsiveness and increased slowness of eating, as well as decreased kcal and fat intake in the offspring. Elevated ApoA1 was associated with increased slowness of eating, lower enjoyment of food and lower kcal, fat and carbohydrate intake. ApoB was positively associated with satiety responsiveness and slowness of eating. Higher TG concentrations were associated with higher food responsiveness. Maternal FFA did not show significant associations. Findings demonstrated that the maternal prenatal lipid profile was associated with offspring’s eating behaviour and energy intake, although not always in the hypothesized direction. View Full-Text
Keywords: CEBQ; eating behaviour; energy intake; foetal programming; FFQ; lipids; pregnancy CEBQ; eating behaviour; energy intake; foetal programming; FFQ; lipids; pregnancy
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Dieberger, A.M.; de Rooij, S.R.; Korosi, A.; Vrijkotte, T.G.M. Maternal Lipid Concentrations during Early Pregnancy and Eating Behaviour and Energy Intake in the Offspring. Nutrients 2018, 10, 1026.

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