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Nutrients 2018, 10(6), 743; https://doi.org/10.3390/nu10060743

A Functional Food Mixture “Protector” Reinforces the Protective Immune Parameters against Viral Flu Infection in Mice

1
Faculty of Pharmacy & Medical Sciences, University of Petra, Amman, Jordan
2
Herbresearch Germany, Wartbergweg 15, D-86874 Mattsies, Germany
3
University of Petra Pharmaceutical Center (UPPC), Amman, Jordan
4
OncoTherapeutica, Inc., Cambridge, MA 02142, USA
*
Author to whom correspondence should be addressed.
Received: 18 April 2018 / Revised: 29 May 2018 / Accepted: 6 June 2018 / Published: 8 June 2018
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Abstract

Background: Viral influenza infection causes serious health issues especially when an outbreak occurs. Although influenza virus vaccines are available and each year manufactures modify the vaccine depending on the expected mutated strain, it is still far from satisfactory, mainly in young children and older adults. Therefore, a product that can support and shape the immune system to protect against viral flu infections is highly essential. Methods: A functional food water-soluble mixture of pomegranate, red grape, dates, olive fruit, figs, and ginger extracts, termed herein “Protector”, was prepared and tested in stimulating/modulating the production of specific cytokines, and hemagglutinin inhibition (HAI) antibodies following viral flu vaccination in mice. Results: A single intraperitoneal or multiple oral administration for 1–7 days of “Protector” significantly increased the production of interferon (IFN)-γ and interleukin (IL)-12 in blood, spleen, and lungs of mice. When “Protector” was orally administered for one week following a single vaccine injection (primary immunization) or for two weeks (one week apart) following double vaccine injections (secondary immunization), mice significantly produced higher titers of HAI antibodies. This increase in HAI antibodies was associated with Pillow-inducing significant and different changes in vaccine-induced IFN-γ, IL-12, IL-6 and IL-22 following primary and secondary immunizations. Conclusions: “Protector” administration reinforces the protective immune parameters against viral flu infection. Therefore, after performing preclinical toxicology studies and ensuring its safety, “Protector” should be considered a potential product to be tested in clinical trials to conclude its efficacy in reducing the devastating effects of flu infection in humans and its outbreaks. View Full-Text
Keywords: pomegranate; red grape; dates; olive fruit; figs; ginger; IFN-γ; IL-12; IL-6; IL-22; flu infection; flu vaccine; hemagglutination inhibition antibodies pomegranate; red grape; dates; olive fruit; figs; ginger; IFN-γ; IL-12; IL-6; IL-22; flu infection; flu vaccine; hemagglutination inhibition antibodies
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Mansoor, K.A.; Qadan, F.; Schmidt, M.; Qinna, N.A.; Badr, M.; Matalka, K.Z. A Functional Food Mixture “Protector” Reinforces the Protective Immune Parameters against Viral Flu Infection in Mice. Nutrients 2018, 10, 743.

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