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Nutrients 2018, 10(5), 598; https://doi.org/10.3390/nu10050598

The Effect of Lean-Seafood and Non-Seafood Diets on Fasting and Postprandial Serum Metabolites and Lipid Species: Results from a Randomized Crossover Intervention Study in Healthy Adults

1
Department of Food Science, Aarhus University, 8000 Aarhus, Denmark
2
Department of Chemistry, Centre for Analysis and Synthesis, Lund University, 221 00 Lund, Sweden
3
Institute of Food Science, Technology and Nutrition (ICTAN), Spanish National Research Council (CSIC), ES-28040 Madrid, Spain
4
Institute of Marine Research, 5817 Bergen, Norway
5
Faculty of Education, Western Norway University of Applied Sciences, 5063 Bergen, Norway
6
School of Nutrition, Université Laval, Laval, G1V 0A6 QC, Canada
7
Hormone Laboratory, Haukeland University Hospital, 5021 Bergen, Norway
8
Department of Clinical Science, University of Bergen, 5020 Bergen, Norway
*
Author to whom correspondence should be addressed.
Received: 10 April 2018 / Revised: 2 May 2018 / Accepted: 9 May 2018 / Published: 11 May 2018
(This article belongs to the Special Issue Fish and Meat Consumption: Risks and Benefits)
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Abstract

The metabolic effects associated with intake of different dietary protein sources are not well characterized. We aimed to elucidate how two diets that varied in main protein sources affected the fasting and postprandial serum metabolites and lipid species. In a randomized controlled trial with crossover design, healthy adults (n = 20) underwent a 4-week intervention with two balanced diets that varied mainly in protein source (lean-seafood versus non-seafood proteins). Nuclear magnetic resonance spectroscopy and liquid chromatography-mass spectrometry analyses were applied to examine the effects of the two diets on serum metabolites. In the fasting state, the lean-seafood diet period, as opposed to the non-seafood diet period, significantly decreased the serum levels of isoleucine and valine, and during the postprandial state, a decreased level of lactate and increased levels of citrate and trimethylamine N-oxide were observed. The non-seafood diet significantly increased the fasting level of 26 lipid species including ceramides 18:1/14:0 and 18:1/23:0 and lysophosphatidylcholines 20:4 and 22:5, as compared to the lean-seafood diet. Thus, the lean-seafood diet decreased circulating isoleucine and valine levels, whereas the non-seafood diet elevated the levels of certain ceramides, metabolites that are associated with insulin-resistance. View Full-Text
Keywords: postprandial; seafood protein; metabolism; TMAO postprandial; seafood protein; metabolism; TMAO
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Schmedes, M.; Balderas, C.; Aadland, E.K.; Jacques, H.; Lavigne, C.; Graff, I.E.; Eng, Ø.; Holthe, A.; Mellgren, G.; Young, J.F.; Sundekilde, U.K.; Liaset, B.; Bertram, H.C. The Effect of Lean-Seafood and Non-Seafood Diets on Fasting and Postprandial Serum Metabolites and Lipid Species: Results from a Randomized Crossover Intervention Study in Healthy Adults. Nutrients 2018, 10, 598.

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