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Nutrients 2018, 10(3), 274; https://doi.org/10.3390/nu10030274

Factors Affecting Gastrointestinal Microbiome Development in Neonates

1
Liggins Institute, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
2
Newborn Services, Auckland City Hospital, Auckland 1023, New Zealand
*
Author to whom correspondence should be addressed.
Received: 13 February 2018 / Revised: 20 February 2018 / Accepted: 23 February 2018 / Published: 28 February 2018
(This article belongs to the Special Issue Diet as Means for studying gut-related Inflammation)
View Full-Text   |   Download PDF [981 KB, uploaded 28 February 2018]   |  

Abstract

The gut microbiome is established in the newborn period and is recognised to interact with the host to influence metabolism. Different environmental factors that are encountered during this critical period may influence the gut microbial composition, potentially impacting upon later disease risk, such as asthma, metabolic disorder, and inflammatory bowel disease. The sterility dogma of the foetus in utero is challenged by studies that identified bacteria, bacterial DNA, or bacterial products in meconium, amniotic fluid, and the placenta; indicating the initiation of maternal-to-offspring microbial colonisation in utero. This narrative review aims to provide a better understanding of factors that affect the development of the gastrointestinal (GI) microbiome during prenatal, perinatal to postnatal life, and their reciprocal relationship with GI tract development in neonates. View Full-Text
Keywords: in utero development; microbiota; vaginal birth; Caesarean-section; infant feeding; Intrapartum antimicrobial prophylaxis; Neonatal Intensive Care Unit; Human milk oligosaccharides in utero development; microbiota; vaginal birth; Caesarean-section; infant feeding; Intrapartum antimicrobial prophylaxis; Neonatal Intensive Care Unit; Human milk oligosaccharides
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Chong, C.Y.L.; Bloomfield, F.H.; O’Sullivan, J.M. Factors Affecting Gastrointestinal Microbiome Development in Neonates. Nutrients 2018, 10, 274.

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