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Nutrients 2018, 10(1), 33; https://doi.org/10.3390/nu10010033

Batzella, Crambe and Monanchora: Highly Prolific Marine Sponge Genera Yielding Compounds with Potential Applications for Cancer and Other Therapeutic Areas

1
Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Univ. Paris-Sud, University of Paris-Saclay, 1, Avenue de la Terrasse, 91198 Gif-Sur-Yvette, France
2
Organic Chemistry Division, Chemistry Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt
3
Institute of Genetics and Animal Breeding of the Polish Academy of Sciences, 05-552 Jastrzebiec, Poland
4
Department of Pharmacognosy, University of Vienna, 1090 Vienna, Austria
5
Department of Pharmaceutical Sciences, College of Pharmacy, Larkin University, 18301 N. Miami Avenue, Miami, FL 33169, USA
6
Queensland Museum, P.O. Box 3300, South Brisbane, QLD BC 4101, Australia
*
Authors to whom correspondence should be addressed.
Received: 1 November 2017 / Revised: 15 December 2017 / Accepted: 22 December 2017 / Published: 2 January 2018
(This article belongs to the Special Issue Natural Products for Cancer Prevention and Therapy)
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Abstract

Pyrroloquinoline and guanidine-derived alkaloids present distinct groups of marine secondary metabolites with structural diversity that displayed potentialities in biological research. A considerable number of these molecular architectures had been recorded from marine sponges belonging to different marine genera, including Batzella, Crambe, Monanchora, Clathria, Ptilocaulis and New Caledonian starfishes Fromia monilis and Celerina heffernani. In this review, we aim to comprehensively cover the chemodiversity and the bioactivities landmarks centered around the chemical constituents exclusively isolated from these three marine genera including Batzella, Crambe and Monanchora over the period 1981–2017, paying a special attention to the polycyclic guanidinic compounds and their proposed biomimetic landmarks. It is concluded that these marine sponge genera represent a rich source of novel compounds with potential applications for cancer and other therapeutic areas. View Full-Text
Keywords: marine sponges; Poecilosclerida; Batzella; Crambe; Monanchora; guanidine alkaloids; pyrroloquinoline alkaloids; bioactivities; biomimetic synthesis marine sponges; Poecilosclerida; Batzella; Crambe; Monanchora; guanidine alkaloids; pyrroloquinoline alkaloids; bioactivities; biomimetic synthesis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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El-Demerdash, A.; Atanasov, A.G.; Bishayee, A.; Abdel-Mogib, M.; Hooper, J.N.A.; Al-Mourabit, A. Batzella, Crambe and Monanchora: Highly Prolific Marine Sponge Genera Yielding Compounds with Potential Applications for Cancer and Other Therapeutic Areas. Nutrients 2018, 10, 33.

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