Vitamin D Vitamers Affect Vitamin D Status Differently in Young Healthy Males
AbstractDietary intake of vitamin D includes vitamin D3 (vitD3), 25-hydroxyvitamin D3 (25OH-D3), and vitamin D2 (vitD2). However, the bioactivity of the different species has not been scientifically established. The hypothesis in this study was that vitD3, 25OH-D3, and vitD2 have an equal effect on 25-hydroxyvitamin D in serum (vitamin D status). To test our hypothesis, we performed a randomized, crossover study. Twelve young males consumed 10 µg/day vitD3 during a four-week run-in period, followed by 3 × 6 weeks of 10 µg/day vitD3, 10 µg/day 25OH-D3, and 10 µg/day vitD2. The content of vitD3, vitD2, 25OH-D3, and 25-hydroxyvitamin D2 (25OH-D2) in serum was quantified by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The hypothesis that the three sources of vitamin D affect vitamin D status equally was rejected. Based on the assumption that 1 µg vitD3/day will show an increase in vitamin D status of 1.96 nmol/L, the results showed that 23 µg vitD2 and 6.8 µg 25OH-D3 was similar to 10 µg vitD3. These results demonstrate that further investigations are necessary to determine how to quantify the total vitamin D activity based on chemical quantification of the individual vitamin D metabolites to replace the total vitamin D activity assessed in biological rat models. View Full-Text
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Jakobsen, J.; Andersen, E.A.W.; Christensen, T.; Andersen, R.; Bügel, S. Vitamin D Vitamers Affect Vitamin D Status Differently in Young Healthy Males. Nutrients 2018, 10, 12.
Jakobsen J, Andersen EAW, Christensen T, Andersen R, Bügel S. Vitamin D Vitamers Affect Vitamin D Status Differently in Young Healthy Males. Nutrients. 2018; 10(1):12.Chicago/Turabian Style
Jakobsen, Jette; Andersen, Elisabeth A.W.; Christensen, Tue; Andersen, Rikke; Bügel, Susanne. 2018. "Vitamin D Vitamers Affect Vitamin D Status Differently in Young Healthy Males." Nutrients 10, no. 1: 12.