Next Article in Journal
Impact of Consuming Extra-Virgin Olive Oil or Nuts within a Mediterranean Diet on DNA Methylation in Peripheral White Blood Cells within the PREDIMED-Navarra Randomized Controlled Trial: A Role for Dietary Lipids
Previous Article in Journal
Association between Malnutrition and 28-Day Mortality and Intensive Care Length-of-Stay in the Critically ill: A Prospective Cohort Study
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessArticle
Nutrients 2018, 10(1), 12; doi:10.3390/nu10010012

Vitamin D Vitamers Affect Vitamin D Status Differently in Young Healthy Males

1
National Food Institute, Technical University of Denmark, 2800 Lyngby, Denmark
2
Institute of Mathematics and Computer Science, Technical University of Denmark, 2800 Lyngby, Denmark
3
Department of Nutrition, Exercise and Sports, University of Copenhagen, 1958 Frederiksberg C, Denmark
*
Author to whom correspondence should be addressed.
Received: 12 October 2017 / Revised: 18 December 2017 / Accepted: 19 December 2017 / Published: 23 December 2017
View Full-Text   |   Download PDF [264 KB, uploaded 23 December 2017]

Abstract

Dietary intake of vitamin D includes vitamin D3 (vitD3), 25-hydroxyvitamin D3 (25OH-D3), and vitamin D2 (vitD2). However, the bioactivity of the different species has not been scientifically established. The hypothesis in this study was that vitD3, 25OH-D3, and vitD2 have an equal effect on 25-hydroxyvitamin D in serum (vitamin D status). To test our hypothesis, we performed a randomized, crossover study. Twelve young males consumed 10 µg/day vitD3 during a four-week run-in period, followed by 3 × 6 weeks of 10 µg/day vitD3, 10 µg/day 25OH-D3, and 10 µg/day vitD2. The content of vitD3, vitD2, 25OH-D3, and 25-hydroxyvitamin D2 (25OH-D2) in serum was quantified by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The hypothesis that the three sources of vitamin D affect vitamin D status equally was rejected. Based on the assumption that 1 µg vitD3/day will show an increase in vitamin D status of 1.96 nmol/L, the results showed that 23 µg vitD2 and 6.8 µg 25OH-D3 was similar to 10 µg vitD3. These results demonstrate that further investigations are necessary to determine how to quantify the total vitamin D activity based on chemical quantification of the individual vitamin D metabolites to replace the total vitamin D activity assessed in biological rat models. View Full-Text
Keywords: 25-hydroxyvitamin D3; vitamin D2; vitamin D3; humans; bioactivity; supplements 25-hydroxyvitamin D3; vitamin D2; vitamin D3; humans; bioactivity; supplements
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Share & Cite This Article

MDPI and ACS Style

Jakobsen, J.; Andersen, E.A.W.; Christensen, T.; Andersen, R.; Bügel, S. Vitamin D Vitamers Affect Vitamin D Status Differently in Young Healthy Males. Nutrients 2018, 10, 12.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top