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Pharmaceutics 2017, 9(4), 54; https://doi.org/10.3390/pharmaceutics9040054

Preparation and Characterization of Carbamazepine Cocrystal in Polymer Solution

1
College of Materials Science and Engineering, North China University of Science and Technology, Tangshan 063210, China
2
Hebei Provincial Key Lab of Inorganic Nonmetallic Materials, College of Materials Science and Engineering, North China University of Science and Technology, Tangshan 063210, China
3
College of Basic Medical Sciences, North China University of Science and Technology, Tangshan 063210, China
*
Author to whom correspondence should be addressed.
Received: 1 October 2017 / Revised: 13 November 2017 / Accepted: 29 November 2017 / Published: 1 December 2017
(This article belongs to the Special Issue Pharmaceutical Crystallisation Science and Engineering)
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Abstract

In this study, we attempted to prepare carbamazepine (CBZ) cocrystal through the solution method in ethanol-water solvent mixture (volume ratio 1:1) and polyvinyl pyrrolidone (PVP) solution. Nicotinamide (NIC) and saccharin (SAC) were selected as cocrystal coformers. Cocrystal screening products were characterized by Fourier Transform Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), and Powder X-ray Diffraction (PXRD) techniques. Characterization results show that in ethanol-water solvent mixture, pure CBZ-NIC cocrystal can be prepared, while CBZ-SAC cocrystal cannot be obtained. The addition of PVP can inhibit CBZ-NIC cocrystal formation and facilitate CBZ-SAC cocrystal formation. View Full-Text
Keywords: cocrystal preparation; polyvinyl pyrrolidone; carbamazepine; nicotinamide; saccharin cocrystal preparation; polyvinyl pyrrolidone; carbamazepine; nicotinamide; saccharin
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Zhang, H.; Zhu, Y.; Qiao, N.; Chen, Y.; Gao, L. Preparation and Characterization of Carbamazepine Cocrystal in Polymer Solution. Pharmaceutics 2017, 9, 54.

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