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Pharmaceutics 2011, 3(2), 307-314; doi:10.3390/pharmaceutics3020307
Article

Influence of the Vehicle on the Penetration of Particles into Hair Follicles

1,* , 1
, 2
, 3
, 4
, 4
, 1
 and 1
1 Center of Experimental and Applied Cutaneous Physiology (CCP), Department of Dermatology and Allergology, Charité – Universitätsmedizin Berlin, 10117 Berlin, Germany 2 Surflay Nanotec GmbH, Schwarzschildstr. 8, 12489 Berlin, Germany 3 Department of Dermatology and Allergology, Charité – Universitätsmedizin Berlin, Tumorimmunology, 10117 Berlin, Germany 4 EMC microcollections GmbH, Sindelfinger Str. 3, 72070 Tübingen, Germany
* Author to whom correspondence should be addressed.
Received: 14 April 2011 / Revised: 30 May 2011 / Accepted: 8 June 2011 / Published: 14 June 2011
(This article belongs to the Special Issue Colloidal Drug Carrier Systems)
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Abstract

Recently, it has been demonstrated that particulate substances penetrate preferentially into the hair follicles and that the penetration depth depends on the particle size. In the present study, the influence of the vehicle of the particulate substances on the penetration depth was investigated. Four different formulations (ethanolic suspension, aqueous suspension, ethanolic gel and aqueous gel) containing peptide-loaded particles of 1 µm in diameter were prepared and applied on porcine ear skin. After penetration, punch biopsies were taken and the penetration depths of the particles were investigated by laser scanning microscopy. The deepest penetration was achieved with the gel formulations demonstrating an influence of the vehicle on the penetration depth of particulate substances.
Keywords: hair follicle; penetration; particle; vehicle; formulation hair follicle; penetration; particle; vehicle; formulation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Patzelt, A.; Richter, H.; Dähne, L.; Walden, P.; Wiesmüller, K.-H.; Wank, U.; Sterry, W.; Lademann, J. Influence of the Vehicle on the Penetration of Particles into Hair Follicles. Pharmaceutics 2011, 3, 307-314.

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