Next Article in Journal
Absolute Oral Bioavailability of Creatine Monohydrate in Rats: Debunking a Myth
Next Article in Special Issue
Hydrogels for Atopic Dermatitis and Wound Management: A Superior Drug Delivery Vehicle
Previous Article in Journal
Prediction of Phase Behavior of Spray-Dried Amorphous Solid Dispersions: Assessment of Thermodynamic Models, Standard Screening Methods and a Novel Atomization Screening Device with Regard to Prediction Accuracy
Article Menu
Issue 1 (March) cover image

Export Article

Open AccessArticle
Pharmaceutics 2018, 10(1), 30; https://doi.org/10.3390/pharmaceutics10010030

Rational Design, Synthesis and Evaluation of γ-CD-Containing Cross-Linked Polyvinyl Alcohol Hydrogel as a Prednisone Delivery Platform

1
Instituto de Química de Recursos Naturales, Universidad de Talca, Talca 3460000, Maule, Chile
2
Centro de Nanotecnología Aplicada, Facultad de Ciencias, Universidad Mayor, Huechuraba 8580000, Región Metropolitana, Chile
3
Centro de Bioinformática y Simulación Molecular (CBSM), Facultad de Ingeniería, Universidad de Talca, Talca 34600000, Maule, Chile
4
Vicerrectoría de Investigación y Postgrado, Universidad Católica del Maule, Talca 3460000, Maule, Chile
5
Department of Clinical Biochemistry and Immunohematology, Faculty of Heatlh Sciences, Universidad de Talca, Talca 3460000, Maule, Chile
6
Center for Studies of Exercise, Metabolism and Cancer (CEMC), Universidad de Chile, Independencia 8380000, Región Metropolitana, Chile
7
Departamento de Microbiología, Facultad de Ciencias de la Salud, Universidad de Talca, Talca 3460000, Maule, Chile
8
Instituto de Innovación Basada en Ciencia, Universidad de Talca, Talca 3460000, Maule, Chile
9
Biomaterials Laboratory Drug Delivery and Controlled Release, Núcleo Científico Multidisciplinario, Dirección de Investigación, Universidad de Talca, Talca 3460000, Maule, Chile
*
Authors to whom correspondence should be addressed.
Received: 30 January 2018 / Revised: 1 March 2018 / Accepted: 4 March 2018 / Published: 7 March 2018
(This article belongs to the Special Issue Smart Hydrogels for Drug Delivery)
View Full-Text   |   Download PDF [10636 KB, uploaded 12 March 2018]   |  

Abstract

This study describes the in-silico rational design, synthesis and evaluation of cross-linked polyvinyl alcohol hydrogels containing γ-cyclodextrin (γ-CDHSAs) as platforms for the sustained release of prednisone (PDN). Through in-silico studies using semi-empirical quantum mechanical calculations, the effectiveness of 20 dicarboxylic acids to generate a specific cross-linked hydrogel capable of supporting different amounts of γ-cyclodextrin (γ-CD) was evaluated. According to the interaction energies calculated with the in-silico studies, the hydrogel made from PVA cross-linked with succinic acids (SA) was shown to be the best candidate for containing γ-CD. Later, molecular dynamics simulation studies were performed in order to evaluate the intermolecular interactions between PDN and three cross-linked hydrogel formulations with different proportions of γ-CD (2.44%, 4.76% and 9.1%). These three cross-linked hydrogels were synthesized and characterized. The loading and the subsequent release of PDN from the hydrogels were investigated. The in-silico and experimental results showed that the interaction between PDN and γ-CDHSA was mainly produced with the γ-CDs linked to the hydrogels. Thus, the unique structures and properties of γ-CDHSA demonstrated an interesting multiphasic profile that could be utilized as a promising drug carrier for controlled, sustained and localized release of PDN. View Full-Text
Keywords: drug delivery; crosslinking; prednisone; cyclodextrins; swelling; accumulative release; thermogravimetric analysis drug delivery; crosslinking; prednisone; cyclodextrins; swelling; accumulative release; thermogravimetric analysis
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Marican, A.; Avila-Salas, F.; Valdés, O.; Wehinger, S.; Villaseñor, J.; Fuentealba, N.; Arenas-Salinas, M.; Argandoña, Y.; Carrasco-Sánchez, V.; Durán-Lara, E.F. Rational Design, Synthesis and Evaluation of γ-CD-Containing Cross-Linked Polyvinyl Alcohol Hydrogel as a Prednisone Delivery Platform. Pharmaceutics 2018, 10, 30.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Pharmaceutics EISSN 1999-4923 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top