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Viruses 2017, 9(9), 260; doi:10.3390/v9090260

A Recombinant HAV Expressing a Neutralization Epitope of HEV Induces Immune Response against HAV and HEV in Mice

1
Department of Molecular Biology, Institute of Medical Biology, Chinese Academy of Medical Sciences, 935 Jiaoling Road, Kunming 650118, China
2
Department of Pathology, The Second Affiliated Hospital of Kunming Medical University, 374 Dianmian Road, Kunming 650101, China
3
Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany
4
German Center for Infection Research (DZIF), Hamburg-Lübeck-Borstel-Riems Site, University of Lübeck, 23562 Lübeck, Germany
5
China Tobacco Yunnan Industrial Co., Ltd., 41 Keyi Road, Kunming 650106, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Curt Hagedorn
Received: 22 July 2017 / Revised: 3 September 2017 / Accepted: 9 September 2017 / Published: 15 September 2017
(This article belongs to the Section Antivirals & Vaccines)
View Full-Text   |   Download PDF [2255 KB, uploaded 20 September 2017]   |  

Abstract

Hepatitis A virus (HAV) and hepatitis E virus (HEV) are causative agents of acute viral hepatitis transmitted via the fecal–oral route. Both viruses place a heavy burden on the public health and economy of developing countries. To test the possibility that HAV could be used as an expression vector for the development of a combination vaccine against hepatitis A and E infections, recombinant HAV-HEp148 was created as a vector to express an HEV neutralization epitope (HEp148) located at aa 459–606 of the HEV capsid protein. The recombinant virus expressed the HEp148 protein in a partially dimerized state in HAV-susceptible cells. Immunization with the HAV-HEp148 virus induced a strong HAV- and HEV-specific immune response in mice. Thus, the present study demonstrates a novel approach to the development of a combined hepatitis A and E vaccine. View Full-Text
Keywords: combined vaccine; hepatitis A; hepatitis E; virus; vector; neutralization epitope combined vaccine; hepatitis A; hepatitis E; virus; vector; neutralization epitope
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Xiang, K.; Kusov, Y.; Ying, G.; Yan, W.; Shan, Y.; Jinyuan, W.; Na, Y.; Yan, Z.; Hongjun, L.; Maosheng, S. A Recombinant HAV Expressing a Neutralization Epitope of HEV Induces Immune Response against HAV and HEV in Mice. Viruses 2017, 9, 260.

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