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Viruses 2017, 9(9), 256; doi:10.3390/v9090256

Geminiviruses and Plant Hosts: A Closer Examination of the Molecular Arms Race

1
ICAR-Indian Institute of Soybean Research, Indian Council of Agricultural Research, Indore 452001, India
2
Department of Plant Pathology, Washington State University, Pullman, WA 99163, USA
3
National Institute of Plant Genome Research, Aruna Asaf Ali Marg, New Delhi110067, India
4
Division of Plant Pathology, Advanced Centre for Plant Virology, ICAR-Indian Agricultural Research Institute (IARI), New Delhi 110012, India
*
Author to whom correspondence should be addressed.
Received: 30 June 2017 / Revised: 2 September 2017 / Accepted: 6 September 2017 / Published: 15 September 2017
(This article belongs to the Special Issue Geminiviruses)
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Abstract

Geminiviruses are plant-infecting viruses characterized by a single-stranded DNA (ssDNA) genome. Geminivirus-derived proteins are multifunctional and effective regulators in modulating the host cellular processes resulting in successful infection. Virus-host interactions result in changes in host gene expression patterns, reprogram plant signaling controls, disrupt central cellular metabolic pathways, impair plant’s defense system, and effectively evade RNA silencing response leading to host susceptibility. This review summarizes what is known about the cellular processes in the continuing tug of war between geminiviruses and their plant hosts at the molecular level. In addition, implications for engineered resistance to geminivirus infection in the context of a greater understanding of the molecular processes are also discussed. Finally, the prospect of employing geminivirus-based vectors in plant genome engineering and the emergence of powerful genome editing tools to confer geminivirus resistance are highlighted to complete the perspective on geminivirus-plant molecular interactions. View Full-Text
Keywords: geminivirus; plant-virus interactions; cellular reprogramming; small non-coding RNAs; viral suppressors geminivirus; plant-virus interactions; cellular reprogramming; small non-coding RNAs; viral suppressors
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Ramesh, S.V.; Sahu, P.P.; Prasad, M.; Praveen, S.; Pappu, H.R. Geminiviruses and Plant Hosts: A Closer Examination of the Molecular Arms Race. Viruses 2017, 9, 256.

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