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Viruses 2017, 9(8), 224; doi:10.3390/v9080224

Hepatitis C Virus-Induced Autophagy and Host Innate Immune Response

Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, 2011 Zonal Avenue, Los Angeles, CA 90033, USA
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Academic Editor: Christian Münz
Received: 5 July 2017 / Revised: 4 August 2017 / Accepted: 11 August 2017 / Published: 12 August 2017
(This article belongs to the Special Issue Viruses and Autophagy)
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Abstract

Autophagy is a catabolic process that is important for maintaining cellular homeostasis. This pathway in hepatocytes is stimulated and controlled by the hepatitis C virus (HCV)—upon infection—to promote its own replication. HCV induces autophagy indirectly and directly through different mechanisms and temporally controls the autophagic flux. This enables the virus to maximize its replication and attenuate the innate immune responses that it activates. In this review, we discuss the relationship between HCV and autophagy, and the crosstalk between HCV-induced autophagy and host innate immune responses. View Full-Text
Keywords: hepatitis C virus; autophagy; innate immunity hepatitis C virus; autophagy; innate immunity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Chan, S.T.; Ou, J.-H.J. Hepatitis C Virus-Induced Autophagy and Host Innate Immune Response. Viruses 2017, 9, 224.

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