Next Article in Journal / Special Issue
Somatic Host Cell Alterations in HPV Carcinogenesis
Previous Article in Journal
Evaluation of Taterapox Virus in Small Animals
Previous Article in Special Issue
Molecular Mechanisms of Human Papillomavirus Induced Skin Carcinogenesis
Article Menu
Issue 8 (August) cover image

Export Article

Open AccessReview
Viruses 2017, 9(8), 208; doi:10.3390/v9080208

Integration of Human Papillomavirus Genomes in Head and Neck Cancer: Is It Time to Consider a Paradigm Shift?

1
Philips Institute for Oral Health Research, Virginia Commonwealth University (VCU) School of Dentistry, Department of Oral and Craniofacial Molecular Biology, Richmond, VA 23298, USA
2
VCU Massey Cancer Center, Richmond, VA 23298, USA
3
VCU Department of Otolaryngology, Richmond, VA 23298, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Alison A. McBride and Karl Munger
Received: 30 June 2017 / Revised: 28 July 2017 / Accepted: 31 July 2017 / Published: 3 August 2017
(This article belongs to the Special Issue Expert Views on HPV Infection)
View Full-Text   |   Download PDF [562 KB, uploaded 4 August 2017]   |  

Abstract

Human papillomaviruses (HPV) are detected in 70–80% of oropharyngeal cancers in the developed world, the incidence of which has reached epidemic proportions. The current paradigm regarding the status of the viral genome in these cancers is that there are three situations: one where the viral genome remains episomal, one where the viral genome integrates into the host genome and a third where there is a mixture of both integrated and episomal HPV genomes. Our recent work suggests that this third category has been mischaracterized as having integrated HPV genomes; evidence indicates that this category consists of virus–human hybrid episomes. Most of these hybrid episomes are consistent with being maintained by replication from HPV origin. We discuss our evidence to support this new paradigm, how such genomes can arise, and more importantly the implications for the clinical management of HPV positive head and neck cancers following accurate determination of the viral genome status. View Full-Text
Keywords: head and neck cancer; human papillomavirus; human papillomavirus 16; HPV16; The Cancer Genome Atlas; oral keratinocytes; integration; episomal; mixed head and neck cancer; human papillomavirus; human papillomavirus 16; HPV16; The Cancer Genome Atlas; oral keratinocytes; integration; episomal; mixed
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Morgan, I.M.; DiNardo, L.J.; Windle, B. Integration of Human Papillomavirus Genomes in Head and Neck Cancer: Is It Time to Consider a Paradigm Shift? Viruses 2017, 9, 208.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top