Evaluation of Taterapox Virus in Small Animals
AbstractTaterapox virus (TATV), which was isolated from an African gerbil (Tatera kempi) in 1975, is the most closely related virus to variola; however, only the original report has examined its virology. We have evaluated the tropism of TATV in vivo in small animals. We found that TATV does not infect Graphiurus kelleni, a species of African dormouse, but does induce seroconversion in the Mongolian gerbil (Meriones unguiculatus) and in mice; however, in wild-type mice and gerbils, the virus produces an unapparent infection. Following intranasal and footpad inoculations with 1 × 106 plaque forming units (PFU) of TATV, immunocompromised stat1−/− mice showed signs of disease but did not die; however, SCID mice were susceptible to intranasal and footpad infections with 100% mortality observed by Day 35 and Day 54, respectively. We show that death is unlikely to be a result of the virus mutating to have increased virulence and that SCID mice are capable of transmitting TATV to C57BL/6 and C57BL/6 stat1−/− animals; however, transmission did not occur from TATV inoculated wild-type or stat1−/− mice. Comparisons with ectromelia (the etiological agent of mousepox) suggest that TATV behaves differently both at the site of inoculation and in the immune response that it triggers. View Full-Text
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Parker, S.; Crump, R.; Hartzler, H.; Buller, R.M. Evaluation of Taterapox Virus in Small Animals. Viruses 2017, 9, 203.
Parker S, Crump R, Hartzler H, Buller RM. Evaluation of Taterapox Virus in Small Animals. Viruses. 2017; 9(8):203.Chicago/Turabian Style
Parker, Scott; Crump, Ryan; Hartzler, Hollyce; Buller, R. M. 2017. "Evaluation of Taterapox Virus in Small Animals." Viruses 9, no. 8: 203.
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