Modulation of Human β-Defensin-1 Production by Viruses
AbstractWhile initially identified as a broad-spectrum antimicrobial peptide, constitutively expressed in epithelia, human β-defensin (hBD)-1 is now recognized to have a more complex pattern of expression of its gene, DEFB1, as well as activities that extend beyond direct antimicrobial. These observations suggest a complex role for hBD-1 in the host defense against viral infections, as evidenced by its expression in cells involved in viral defense, and its gene regulation in response to viral challenge. This regulation is observed both in vitro and in vivo in humans, as well as with the murine homolog, mBD-1. While numerous reviews have summarized the existing literature on β-defensin gene expression and activity, here we provide a focused review of relevant studies on the virus-mediated regulation of hBD-1 and how this regulation can provide a crucial aspect of the innate immune defense against viral infection. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Ryan, L.K.; Diamond, G. Modulation of Human β-Defensin-1 Production by Viruses. Viruses 2017, 9, 153.
Ryan LK, Diamond G. Modulation of Human β-Defensin-1 Production by Viruses. Viruses. 2017; 9(6):153.Chicago/Turabian Style
Ryan, Lisa K.; Diamond, Gill. 2017. "Modulation of Human β-Defensin-1 Production by Viruses." Viruses 9, no. 6: 153.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.