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Viruses 2017, 9(6), 153; doi:10.3390/v9060153

Modulation of Human β-Defensin-1 Production by Viruses

1
University of Florida College of Medicine, Division of Infectious Disease, Department of Medicine and Global Medicine, 1600 SW Archer Road, Box 100277, Gainesville, FL 32610, USA
2
University of Florida College of Dentistry, Department of Oral Biology, 1600 SW Archer Road, Box 100424, Gainesville, FL 32610, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Theresa Li-Yun Chang
Received: 1 May 2017 / Revised: 13 June 2017 / Accepted: 16 June 2017 / Published: 21 June 2017
(This article belongs to the Special Issue Defensins)
View Full-Text   |   Download PDF [848 KB, uploaded 21 June 2017]   |  

Abstract

While initially identified as a broad-spectrum antimicrobial peptide, constitutively expressed in epithelia, human β-defensin (hBD)-1 is now recognized to have a more complex pattern of expression of its gene, DEFB1, as well as activities that extend beyond direct antimicrobial. These observations suggest a complex role for hBD-1 in the host defense against viral infections, as evidenced by its expression in cells involved in viral defense, and its gene regulation in response to viral challenge. This regulation is observed both in vitro and in vivo in humans, as well as with the murine homolog, mBD-1. While numerous reviews have summarized the existing literature on β-defensin gene expression and activity, here we provide a focused review of relevant studies on the virus-mediated regulation of hBD-1 and how this regulation can provide a crucial aspect of the innate immune defense against viral infection. View Full-Text
Keywords: hBD-1; DEFB1; antimicrobial peptide; virus; monocytes; plasmacytoid dendritic cells; innate immunity; epithelial cells; defensin; gene regulation hBD-1; DEFB1; antimicrobial peptide; virus; monocytes; plasmacytoid dendritic cells; innate immunity; epithelial cells; defensin; gene regulation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Ryan, L.K.; Diamond, G. Modulation of Human β-Defensin-1 Production by Viruses. Viruses 2017, 9, 153.

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