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Viruses 2017, 9(5), 99; doi:10.3390/v9050099

Porcine Circovirus Type 2 (PCV2) Vaccines in the Context of Current Molecular Epidemiology

1
Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA
2
The Roslin Institute and the Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian EH25 9RG, UK
*
Author to whom correspondence should be addressed.
Academic Editors: Linda Dixon and Simon Graham
Received: 3 March 2017 / Revised: 27 April 2017 / Accepted: 28 April 2017 / Published: 6 May 2017
(This article belongs to the Special Issue Porcine Viruses)
View Full-Text   |   Download PDF [256 KB, uploaded 6 May 2017]

Abstract

Porcine circovirus type 2 (PCV2) is an economically important swine pathogen and, although small, it has the highest evolution rate among DNA viruses. Since the discovery of PCV2 in the late 1990s, this minimalistic virus with a 1.7 kb single-stranded DNA genome and two indispensable genes has become one of the most important porcine pathogens, and presently is subjected to the highest volume of prophylactic intervention in the form of vaccines in global swine production. PCV2 can currently be divided into five different genotypes, PCV2a through PCV2e. It is well documented that PCV2 continues to evolve, which is reflected by changes in the prevalence of genotypes. During 2006, commercial vaccines for PCV2 were introduced on a large scale in a pig population mainly infected with PCV2b. Since 2012, the PCV2d genotype has essentially replaced the previously predominant PCV2b genotype in North America and similar trends are also documented in other geographic regions such as China and South Korea. This is the second major PCV2 genotype shift since the discovery of the virus. The potential increase in virulence of the emergent PCV2 genotype and the efficacy of the current vaccines derived from PCV2a genotype against the PCV2d genotype viruses has received considerable attention. This review attempts to synthesize the understanding of PCV2 biology, experimental studies on the antigenic variability, and molecular epidemiological analysis of the evolution of PCV2 genotypes. View Full-Text
Keywords: PCV2; epidemiology; pigs; vaccination PCV2; epidemiology; pigs; vaccination
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Karuppannan, A.K.; Opriessnig, T. Porcine Circovirus Type 2 (PCV2) Vaccines in the Context of Current Molecular Epidemiology. Viruses 2017, 9, 99.

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