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Viruses 2017, 9(5), 95; doi:10.3390/v9050095

Interplay between the Hepatitis B Virus and Innate Immunity: From an Understanding to the Development of Therapeutic Concepts

Cancer Research Center of Lyon (CRCL), INSERM, U1052, CNRS, University of Lyon, UMR-5286, 69003 Lyon, France
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Academic Editors: Ulrike Protzer and Michael Nassal
Received: 12 March 2017 / Revised: 24 April 2017 / Accepted: 24 April 2017 / Published: 28 April 2017
(This article belongs to the Special Issue Recent Advances in Hepatitis B Virus Research)
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Abstract

The hepatitis B virus (HBV) infects hepatocytes, which are the main cell type composing a human liver. However, the liver is enriched with immune cells, particularly innate cells (e.g., myeloid cells, natural killer and natural killer T-cells (NK/NKT), dendritic cells (DCs)), in resting condition. Hence, the study of the interaction between HBV and innate immune cells is instrumental to: (1) better understand the conditions of establishment and maintenance of HBV infections in this secondary lymphoid organ; (2) define the role of these innate immune cells in treatment failure and pathogenesis; and (3) design novel immune-therapeutic concepts based on the activation/restoration of innate cell functions and/or innate effectors. This review will summarize and discuss the current knowledge we have on this interplay between HBV and liver innate immunity. View Full-Text
Keywords: HBV; liver immunity; innate immunity; viral escape; immune therapeutic concepts HBV; liver immunity; innate immunity; viral escape; immune therapeutic concepts
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Faure-Dupuy, S.; Lucifora, J.; Durantel, D. Interplay between the Hepatitis B Virus and Innate Immunity: From an Understanding to the Development of Therapeutic Concepts. Viruses 2017, 9, 95.

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