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Viruses 2017, 9(2), 29; doi:10.3390/v9020029

A Review of the Strain Diversity and Pathogenesis of Chicken Astrovirus

Agri-Food and Biosciences Institute, Stormont Laboratory, Stoney Road, Belfast, BT4 3SD, UK
Academic Editor: Stacey Schulz-Cherry
Received: 4 January 2017 / Revised: 25 January 2017 / Accepted: 25 January 2017 / Published: 10 February 2017
(This article belongs to the Special Issue Astroviruses)
View Full-Text   |   Download PDF [548 KB, uploaded 10 February 2017]   |  

Abstract

Although a relatively recently emerged virus, identified only in 2004 as a separate species of avian astrovirus, chicken astrovirus (CAstV) has been associated with poor growth of broiler flocks, enteritis and diarrhea and is a candidate pathogen in cases of runting stunting syndrome. More recently CAstV has been implicated in cases of two other diseases of broilers as the sole etiological agent, namely severe kidney disease of young broilers with visceral gout and the “White Chicks” hatchery disease. Examination of the strains of CAstV associated with the two latter diseases reveals they are closely related genetically. This review will discuss the pathogenesis of CAstV in relation to strain diversity and the effects of vertical versus horizontal transmission, virus load, co-infections and age of bird at infection, all factors that may impact upon disease severity. View Full-Text
Keywords: chicken astrovirus; strain diversity; pathogenesis chicken astrovirus; strain diversity; pathogenesis
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Smyth, V.J. A Review of the Strain Diversity and Pathogenesis of Chicken Astrovirus. Viruses 2017, 9, 29.

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