Next Article in Journal
Genetic Assessment of African Swine Fever Isolates Involved in Outbreaks in the Democratic Republic of Congo between 2005 and 2012 Reveals Co-Circulation of p72 Genotypes I, IX and XIV, Including 19 Variants
Next Article in Special Issue
Non-Canonical Roles of Dengue Virus Non-Structural Proteins
Previous Article in Journal
Microscopic Characterization of the Brazilian Giant Samba Virus
Previous Article in Special Issue
Envelope Protein Mutations L107F and E138K Are Important for Neurovirulence Attenuation for Japanese Encephalitis Virus SA14-14-2 Strain
Article Menu
Issue 2 (February) cover image

Export Article

Open AccessArticle
Viruses 2017, 9(2), 28; doi:10.3390/v9020028

Prevalence and Clinical Impact of Human Pegivirus-1 Infection in HIV-1-Infected Individuals in Yunnan, China

1
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China
2
Department of Infectious Diseases, Yunnan Provincial Hospital of Infectious Diseases, Kunming 650301, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Michael R. Holbrook
Received: 6 December 2016 / Revised: 20 January 2017 / Accepted: 25 January 2017 / Published: 15 February 2017
(This article belongs to the Special Issue Advances in Flavivirus Research)
View Full-Text   |   Download PDF [1522 KB, uploaded 15 February 2017]   |  

Abstract

Human Pegivirus-1 (HPgV-1) may have a beneficial impact on disease progression in human immunodeficiency virus-1 (HIV-1) infection. However, analysis of the genotypic diversity of HPgV-1 and its relevance to the progression of HIV-1 disease remains limited. A total of 1062 HIV-1-infected individuals were recruited in all sixteen prefectures of Yunnan province, China. The reverse transcription nested polymerase chain reaction (RT-nPCR), phylogenetic analyses, and clinical data analyses were used to detect HPgV-1 infection, determine genotype, and analyze HPgV-1 genotype impact on HIV-1 disease progression. The overall positive rate of HPgV-1 RNA was 23.4% (248/1062), and the frequency of HPgV-1 infection in injecting drug users (IDUs) (28.5%, 131/460) was significantly higher than in heterosexuals (19.4%, 117/602). Multiple genotypes were identified in 212 subjects with successful sequencing for the E2 gene, including genotype 7 (55.7%), genotype 3 (34.9%), genotype 4 (4.7%), genotype 2 (3.3%), and an unclassified group (1.4%). Moreover, genotype 7 predominated in IDUs, whereas genotype 3 was the most common in heterosexuals. Our results revealed that HPgV-1 genotype 7 groups exhibited significantly lower HIV-1 viral load and higher CD4+ cell counts. This finding suggests that HPgV-1 genotype 7 may be associated with a better progression of HIV-1 disease. View Full-Text
Keywords: HPgV-1; HIV-1; HCV; co-infection; injecting drug users; heterosexuals; genotypic diversity; clinical effect HPgV-1; HIV-1; HCV; co-infection; injecting drug users; heterosexuals; genotypic diversity; clinical effect
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Miao, Z.; Gao, L.; Song, Y.; Yang, M.; Zhang, M.; Lou, J.; Zhao, Y.; Wang, X.; Feng, Y.; Dong, X.; Xia, X. Prevalence and Clinical Impact of Human Pegivirus-1 Infection in HIV-1-Infected Individuals in Yunnan, China. Viruses 2017, 9, 28.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top